Three murine anxiety models: results from multiple inbred strain comparisons

Genes, Brain, and Behavior
L C Milner, John C Crabbe

Abstract

The literature surrounding rodent models of human anxiety disorders is discrepant concerning which models reflect anxiety-like behavior distinct from general activity and whether different models are measuring the same underlying constructs. This experiment compared the responses of 15 inbred mouse strains (129S1/SvlmJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57L/J, CBA/J, CE/J, DBA/2J, FVB/NJ, NZB/B1NJ, PL/J, SJL/J and SWR/J) in three anxiety-like behavioral tasks (light/dark test, elevated zero-maze and open field) to examine whether responses were phenotypically and/or genetically correlated across tasks. Significant strain differences were found for all variables examined. Principal components analyses showed that variables associated with both activity and anxiety-like behaviors loaded onto one factor, while urination and defecation loaded onto another factor. Our findings differ from previous research by suggesting that general activity and anxiety-related behaviors are linked, negatively correlated and cannot easily be dissociated in these assays. However, these findings may not necessarily generalize to other unconditioned anxiety-like behavioral tests.

References

Apr 11, 1979·Psychopharmacology·G T Pollard, J L Howard
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Mar 1, 1981·Behavior Genetics·J P Hegmann, B Possidente
Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Jan 1, 1993·Psychopharmacology·S L Handley, J W McBlane
Sep 1, 1995·Behavioural Brain Research·Y ClémentG Chapouthier
May 1, 1996·Behavioural Brain Research·P V Guillot, G Chapouthier
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·A Ramos, P Mormède
Dec 2, 1998·Behavioural Pharmacology·R J Rodgers
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·S M WeissC T Dourish
Sep 9, 2000·Behavior Genetics·D F AvgustinovichN N Kudryavtseva
Sep 21, 2000·Behavioural Brain Research·M M van Gaalen, T Steckler
Sep 22, 2001·Physiology & Behavior·K L McIlwainR Paylor
Oct 30, 2001·Behavioural Brain Research·C Belzung, G Griebel
Nov 14, 2002·Behavioural Brain Research·J Adriaan Bouwknecht, Richard Paylor
Jun 5, 2003·Psychopharmacology·Christopher L KliethermesJohn C Crabbe
Mar 3, 2004·Behavior Genetics·Norman D HendersonJonathan Flint
Mar 23, 2004·Behavioural Brain Research·Valeria CarolaFranco Mangia
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·John C CrabbeDouglas Wahlsten
Aug 9, 2005·Neuroscience and Biobehavioral Reviews·A P Carobrez, L J Bertoglio
May 9, 2006·Pharmacology, Biochemistry, and Behavior·Tamara L DoremusLinda P Spear
Aug 5, 2006·Genetics·William ValdarJonathan Flint
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Douglas WahlstenJohn C Crabbe
Jan 20, 2007·Genes, Brain, and Behavior·J S RhodesJ C Crabbe
Oct 30, 1999·Behavioural Processes·C KoppR Misslin

❮ Previous
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Citations

May 11, 2010·Psychopharmacology·Leanne M FraserAndré Ramos
Jan 5, 2013·Behavior Genetics·Timothy P O'LearyRichard E Brown
May 1, 2010·Nature Protocols·Daniela D PollakGert Lubec
Oct 3, 2008·Behavioural Pharmacology·Jonathan L BrigmanAndrew Holmes
Feb 13, 2010·Addiction Biology·Markus HeiligHoward C Becker
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Khyobeni MozhuiAndrew Holmes
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth T BanksElizabeth M C Fisher
Sep 9, 2011·Future Neurology·Simone B SartoriNicolas Singewald
Jun 10, 2014·Physiology & Behavior·A Ennaceur
Jan 30, 2016·Molecular Brain·Hirotaka ShojiTsuyoshi Miyakawa
Dec 3, 2014·Neurotoxicology and Teratology·Brenna M FlanneryPamela J Lein
May 4, 2010·Brain Research Bulletin·Laura C AmannSteven J Siegel
Nov 11, 2008·Behavioural Brain Research·F E HarrisonM P McDonald
Nov 26, 2008·Physiology & Behavior·Christine M WooleyKevin L Seburn
Oct 11, 2015·Behavioural Brain Research·Alexander V KulikovEgor B Prokhortchouk
Sep 28, 2014·Brain Research·Stephanie L BakerCatherine Bielajew
Apr 14, 2016·Pharmacology Research & Perspectives·Abdelkader Ennaceur, Paul L Chazot
Jul 12, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L WangY Taché
Nov 19, 2013·Journal of Neurochemistry·Alexander BarthAndreas Zimmer
Jun 9, 2015·Behavioural Brain Research·Klaudia SzklarczykRyszard Przewlocki
Jun 1, 2013·Behavioural Brain Research·Andrew E ArrantCynthia M Kuhn
Mar 31, 2015·Pharmacology, Biochemistry, and Behavior·Trey ThompsonLisa M Tarantino
Dec 20, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luis HerediaJosé L Domingo
Aug 30, 2008·Trends in Pharmacological Sciences·André Ramos
Apr 30, 2013·The American Journal of Pathology·Olivier BiondiFrançois-Jérôme Authier
Jun 12, 2016·Alcohol·Morgan L SekhonChristopher L Kliethermes

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