Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.

Pharmacological Reports : PR
Pavel MarešHana Kubová

Abstract

Postictal potentiation presented immediately after cortical seizures in immature rats might be due to imbalance between excitation and inhibition. The aim of the present study was to determine whether augmentation of inhibition mediated by GABAA receptors could also suppress the postictal potentiation. Twelve-day old rats with implanted electrodes were used in our study. Five drugs were tested: the agonist muscimol, the positive modulator midazolam and three neurosteroids affecting GABAA receptors-allopregnanolone, pregnanolone sulphate and pregnanolone glutamate. None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures. Our results support a role of GABA in augmentation of cortical after discharges after longer intervals, whereas immediate postictal potentiation is not affected by GABAergic drugs. Due to similar effect with GABAergic drugs, the main mechanism of action of the three steroids tested is potentiation of GABAergic inhibition.

References

Sep 1, 1978·Neurosurgery·R Racine
Nov 1, 1992·Annals of Neurology·M J During, D D Spencer
Feb 1, 1991·Journal of Neurophysiology·H J Luhmann, D A Prince
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Sep 5, 2002·Nature Reviews. Neuroscience·Yehezkel Ben-Ari
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Bo LiuEdward G Jones
Jun 13, 2008·The European Journal of Neuroscience·Roman TyzioRustem Khazipov
Oct 17, 2017·European Journal of Pharmacology·Pavel Mareš
Mar 17, 2018·Vitamins and Hormones·Doodipala Samba Reddy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Epileptic Disorders : International Epilepsy Journal with Videotape
Fritz Leutmezer, Christoph Baumgartner
Epilepsy & Behavior : E&B
Soheyl Noachtar, Dieter Schmidt
Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association
Deborah Blazys
Progress in Neuro-psychopharmacology & Biological Psychiatry
S Caldecott-Hazard, J Engel
© 2022 Meta ULC. All rights reserved