Three new and antitumor anthraquinone glycosides from Lasianthus acuminatissimus MERR

Chemical & Pharmaceutical Bulletin
Bin LiXiao-Guang Chen

Abstract

Three new anthraquinone glycosides, lasianthuoside A (1), B (2), and C (3), were isolated from the root of Lasianthus acuminatissimus MERR., The structural elucidation of these anthraquinones was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Ten known compounds, damnacanthol (4), damnacanthol 11-methyl ether (5), damnacanthol-3-O-beta-D-primeveroside (6), asperuloside (7), asperulosidic acid (8), deacetyl asperulosidic acid (9), a nonglycosidic iridoid (10), 2,6-dimethoxy-4-hydroxyphenol-1-O-beta-D-glucopyranoside (11), tachioside (methoxyhydroquinone-4-O-beta-D-glucopyranoside) (12), and isotachioside (methoxyhydroquinone-1-O-beta-D-glucopyranoside) (13) were also identified for the first time from this plant in the course of the phytochemical and spectroscopic investigation. In addition to this report, a preliminary evaluation of 13 compounds in treating rheumatoid arthritis and antitumor effects of six anthraquinones are presented.

References

Oct 10, 2002·Chemical & Pharmaceutical Bulletin·Yoshio TakedaHideaki Otsuka
Jul 26, 2003·Journal of Natural Products·Ximena ChiribogaGiovanni Vidari

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Citations

Dec 29, 2013·Journal of Analytical Methods in Chemistry·De-Lu MaBrett J West
Oct 4, 2006·Chemical & Pharmaceutical Bulletin·Abdolmajid Bayandori MoghaddamMaryam Latifi
Jun 17, 2016·Glycoconjugate Journal·Brett J WestC Jarakae Jensen
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingqiu ShanSam Fong Yau Li
Feb 3, 2015·Chemistry & Biodiversity·Wen-Hui XuPing Zhao
Nov 9, 2019·Natural Product Research·Xingxing LiuBin Li
May 14, 2020·Natural Product Research·Rhian Jaymar D RamilKenroh Sasaki
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gadah Abdulaziz Al-HamoudKatsuyoshi Matsunami
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gadah Abdulaziz Al-HamoudKatsuyoshi Matsunami
Sep 21, 2021·Natural Product Research·Nguyen Kim Tuyen PhamTan Phat Nguyen

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