Three new diterpenes from the marine soft coral Lobophytum crassum

Journal of Natural Products
G F MatthéeA D Wright

Abstract

Three new terpenoid metabolites (1-3) were isolated from the CH2Cl2 extract of the soft coral Lobophytum crassum together with the eudesmane derivative 4 and the known cembrane (2S,7S,8S)-sarcophytoxide (5). Compound 1 is a new cembrane-based diterpene with an C7-C8-epoxide and a methyl ester functionality at C-16. (3E,5Z)- (2) and (3Z,5E)-2-methyl-6-(4a'-methyl-8'-methylene-trans-perhydr onaphthalen-2'-yl)hepta-3,5-dien-2-ol (3) represent two new carbon-carbon double bond isomers of 4, which has the 3E,5E-configuration. The structures of 1-5 were established by interpretation of their spectroscopic data, mainly 1D and 2D NMR and MS. Biological activity evaluation of compounds 1 and 5 and the crude extracts was carried out using agar diffusion assays toward microbial targets and ELISA assays for investigating the inhibition of HIV-1 reverse transcriptase and p56lck tyrosine kinase.

References

Dec 1, 1994·Planta medica·G M KönigJ M Pezzuto
Jul 1, 1996·Journal of Natural Products·A D WrightR Desqueyroux-Faúndez

❮ Previous
Next ❯

Citations

Oct 1, 2011·Journal of Natural Products·Liang LiYue-Wei Guo
Mar 14, 2012·Marine Drugs·Shang-Kwei Wang, Chang-Yih Duh
Apr 24, 2013·Marine Drugs·Ching-Yen LinKao-Jean Huang
Sep 6, 2011·Marine Drugs·Shi-Yie ChengChang-Yih Duh
Mar 1, 2012·Marine Drugs·Shih-Tseng LinChang-Yih Duh
Feb 5, 2014·Chemical & Pharmaceutical Bulletin·Nguyen Xuan CuongChau Van Minh
May 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Prodip K RoyKatsuhiro Ueda
May 13, 2009·Bioorganic & Medicinal Chemistry·Shi-Yie ChengChang-Yih Duh
Jan 18, 2014·Chemical & Pharmaceutical Bulletin·Min ZhaoPengcheng Yan
Aug 19, 2004·Molecular Ecology·Steven V Vollmer, Stephen R Palumbi
Nov 13, 2008·Journal of Asian Natural Products Research·Si-Han ChenYue-Wei Guo
Oct 27, 2017·Marine Drugs·Kuei-Hung LaiJui-Hsin Su
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui LyuYu Chen
Jul 10, 2009·Organic Letters·Shih-Tseng LinChang-Yih Duh
Jun 1, 2005·Journal of Natural Products·Guoqiang LiWenhan Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.