PMID: 11918464Mar 29, 2002Paper

Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide

Journal of Child Neurology
Ilo E Leppik

Abstract

During the last decade, nine new antiepileptic drugs were approved for use by the US Food and Drug Administration. The characteristics of three of these new antiepileptic drugs-levetiracetam, oxcarbazepine, and zonisamide--are reviewed here. Their individual characteristics, including mechanism of action, efficacy, safety, and pharmacokinetics, are compared, and their effectiveness in treating specific seizure types is noted. As with all antiepileptic drugs, the efficacy, side-effect, and pharmacokinetic profiles must be matched to each individual's clinical profile to attain the maximum benefit. All three are unique and will be useful in expanding the aggregate of therapies available to clinicians treating diverse epilepsy syndromes and seizure types. This review focuses on results in adults; pediatric experience is reported in other articles in this supplement.

References

Jun 1, 1988·Neurology·T R HenryM Jacobs
Nov 1, 1987·Epilepsia·G H FrommC F Terrence
Feb 1, 1993·Epilepsy Research·I E LeppikJ D Wallace
Nov 9, 1996·BMJ : British Medical Journal·A G MarsonD W Chadwick
Feb 26, 1998·Epilepsy Research·M Kyllerman, E Ben-Menachem
Nov 28, 2001·Neurology·E FaughtUNKNOWN Zonisamide 922 Trial Group

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Citations

Feb 14, 2014·Advances in Therapy·Joanna H CoxAndrea E Cavanna
Oct 23, 2010·Ecotoxicology and Environmental Safety·Nikolay Strigul
Dec 26, 2003·Pharmacotherapy·Melody RyanRobert J Baumann
Dec 17, 2005·Epilepsy & Behavior : E&B·Ahmad K Kaddurah, Gregory L Holmes
Dec 9, 2014·Experimental Neurology·Robert J Kotloski, Thomas P Sutula
May 29, 2004·Therapeutic Drug Monitoring·Michael V MilesRobert J Baumann
Sep 26, 2008·International Labour Review·Deborah LevisonSuzanne Duryea
Dec 22, 2009·American Journal of Industrial Medicine·John M DementPatricia Quinn
May 29, 2010·Child: Care, Health and Development·R B A de VasconcelosR Q Gurgel
Sep 1, 2005·MCN. the American Journal of Maternal Child Nursing·Susana Marin
Nov 9, 2011·Journal of Korean Medical Science·Won-Jeong LeeKurt Georg Hering
Jan 28, 2003·Therapeutic Drug Monitoring·Shellee A GrimRobert J Baumann
May 13, 2010·Journal of Neuro-oncology·M MaschioB Jandolo
Apr 25, 2012·Journal of Neuro-oncology·Marta Maschio, Loredana Dinapoli

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