Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Tao ZhangZhong-Mei Zou

Abstract

Three new highly oxygenated (2⁻4), and two known (1 and 5) germacranolides, were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds 2⁻4 were determined using similar CD spectra with 1. The new compound 2 and the known compound 5 exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control cis-platin.

References

Dec 11, 1997·Journal of Natural Products·D K KimO P Zee
Jan 6, 1999·Archives of Pharmacal Research·O P ZeeK R Lee
May 7, 1999·Archives of Pharmacal Research·O P ZeeK R Lee
Dec 30, 2003·Journal of Natural Products·Chao YangZhongjian Jia
Feb 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Be-Jen WangChun-Li Su
Apr 17, 2007·Journal of Natural Products·Xue GaoZhong-Jian Jia
May 27, 2009·Phytotherapy Research : PTR·Ill-Min ChungHyung-In Moon
Nov 27, 2010·Bioorganic & Medicinal Chemistry Letters·Xu-Wen LiJin-Feng Hu
Mar 23, 2011·Canadian Journal of Physiology and Pharmacology·Hwa Jin LeeJae-Ha Ryu
May 9, 2012·Fitoterapia·Wei-Dong XieKyung-Ho Row
Feb 3, 2015·Journal of Ethnopharmacology·Jian-Ping ZhangWei-Dong Zhang

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Citations

Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia KłeczekAnna Stojakowska
Mar 15, 2019·Journal of Natural Products·Nan-Lin ZhuYang Ye
Oct 10, 2020·Journal of Natural Products·Li ZhuLing-Yi Kong

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Methods Mentioned

BETA
NMR
X-ray
column chromatography

Software Mentioned

CrysAlisPro
SHELXL
Origin

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