Three new lignanamides from the root of Lycium chinense with anti-inflammatory activity

Natural Product Research
Fang ChenGuang-Xiong Zhou

Abstract

Three new lignanamides, that is, a new lignanamide (1), and a pair of enantiomers (2a and 2b) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of Lycium chinense. The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound 2a showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 value of 10.77 ± 2.14 μM, comparing to that of positive control quercetin (17.21 ± 0.50 μM).

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Citations

Feb 1, 2020·Natural Product Research·Yuan-Peng HuangGuang-Xiong Zhou
May 6, 2020·Critical Reviews in Food Science and Nutrition·William LeonardZhongxiang Fang
Mar 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fangya PanJiulong Xie
Jan 19, 2021·Natural Product Research·Ahmed OthmanKuniyoshi Shimizu
Apr 1, 2021·Journal of Natural Products·Annemiek van ZadelhoffJean-Paul Vincken

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