Three novel, multiple recombinant types of species of human mastadenovirus D (HAdV-D 73, 74 & 75) isolated from diarrhoeal faeces of immunocompromised patients

The Journal of General Virology
Elias HageAlbert Heim

Abstract

Species D is the largest of the seven species of human mastadenoviruses (HAdV), but few of its multiple types are associated with asevere disease, e.g. epidemic keratoconjunctivitis. Many other types are hardly ever associated with significant diseases in immunocompetent patients, but have been isolated from the diarrhoeal faeces of terminal AIDS patients suggesting their role as opportunistic pathogens. Three novel HAdV-D strains were isolated from the faeces of three immunocompromised adult patients (clinical diagnoses: lymphoma, myelodysplastic syndrome and AIDS CDC3B, respectively). These strains were not typeable by imputed serology of the hexon and fibre gene and therefore complete genomic sequences were generated by next-generation sequencing (NGS). All three strains were multiple recombinants and fulfilled the criteria for designation as types 73, 74 and 75 with the penton/hexon/fibre genotype codes P67H45F27, P70H74F51 and P75H26F29, respectively. A novel genomic backbone and also a novel hexon neutralization epitope sequence were discovered in type 74, and a novel penton sequence in type 75. At the complete genome level, types 73, 74 and 75 were closely related neither to each other nor to type 70, which was previousl...Continue Reading

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Citations

May 15, 2018·Human Gene Therapy Methods·Wenli ZhangAnja Ehrhardt
Sep 25, 2018·Microbial Genomics·Charlotte J HouldcroftAnkur Mutreja
Nov 24, 2019·FEBS Letters·Jian GaoAnja Ehrhardt
Nov 26, 2019·FEBS Letters·Matthew CharmanMatthew D Weitzman
Apr 16, 2019·Frontiers in Molecular Neuroscience·Danila Del RioEric J Kremer
Nov 27, 2019·FEBS Letters·Ashrafali Mohamed IsmailJames Chodosh
Sep 6, 2020·International Journal of Molecular Sciences·Wenli ZhangAnja Ehrhardt
Dec 17, 2020·Viruses·Xavier Fernandez-CassiRosina Girones
Sep 11, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Naiying MaoWenbo Xu

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