PMID: 9442492Jan 1, 1997Paper

Three predominant clones identified within penicillin-resistant South African isolates of Streptococcus pneumoniae

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
A M Smith, K P Klugman

Abstract

The worldwide spread of antibiotic-resistant pneumococcal clones is cause for concern. In South Africa, penicillin-resistant pneumococci are mostly associated with serogroups 6 and 19, therefore, we have analyzed the clonal relationships between resistant isolates of these two serogroups. DNA fingerprinting of penicillin-binding protein genes and arbitrarily-primed PCR, have identified two penicillin-resistant pneumococcal clones of serotype 19A and serotype 6B, and a third multi-resistant serotype 19A clone, of which all three clones are predominant within South Africa's penicillin-resistant pneumococcal population. These clones are represented by strains isolated from hospitals that are widely separated in South Africa. Further studies are required to establish whether these clones have expanded in the rest of Africa or spread to other continents.

References

Mar 1, 1980·Antimicrobial Agents and Chemotherapy·S Zighelboim, A Tomasz
Apr 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A M FigueiredoA Tomasz

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Citations

Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M C VelaE Castañeda
May 29, 2007·The Pediatric Infectious Disease Journal·Keith P Klugman, Lesley McGee
Oct 26, 2002·Journal of Bacteriology·D Ashley RobinsonSusan K Hollingshead
Apr 3, 2003·Journal of Advanced Nursing·Susan Halford, Pauline Leonard
Mar 7, 2001·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases· Huebner REK P Klugman
May 20, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·P Nilsson, M H Laurell
May 15, 1999·Journal of Clinical Microbiology·K OverwegW Hryniewicz

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