PMID: 6965518Feb 7, 1980Paper

Three-receptor, clonal expansion model for selection of self-recognition in the thymus

Nature
A R Williamson

Abstract

The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.

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Citations

Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·O Söder
Mar 1, 1983·Veterinary Immunology and Immunopathology·D E Onions
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S CarelG Corradin
Oct 1, 1993·Immunological Reviews·P Matzinger
Oct 1, 1984·Immunological Reviews·M M DavisS M Hedrick
Jan 1, 1984·European Journal of Immunology·M S SandrinI F McKenzie
Aug 6, 1981·Nature·P Matzinger
May 24, 1984·Nature·Y H ChienM M Davis
Nov 1, 1984·Nature·Y ChienM M Davis

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