Three roads to islet bursting: emergent oscillations in coupled phantom bursters

Biophysical Journal
Charles L ZimlikiArthur Sherman

Abstract

Glucose-induced membrane potential and Ca(2+) oscillations in isolated pancreatic beta-cells occur over a wide range of frequencies, from >6/min (fast) to <1/min (slow). However, cells within intact islets generally oscillate with periods of 10-60 s (medium). The phantom bursting concept addresses how beta-cells can generate such a wide range of frequencies. Here, we explore an updated phantom bursting model to determine how heterogeneity in a single parameter can explain both the broad frequency range observed in single cells and the rarity of medium oscillations. We then incorporate the single-cell model into an islet model with parameter heterogeneity. We show that strongly coupled islets must be composed of predominantly medium oscillating single cells or a mixture of fast and slow cells to robustly produce medium oscillations. Surprisingly, we find that this constraint does not hold for moderate coupling, and that robustly medium oscillating islets can arise from populations of single cells that are essentially all slow or all fast. Thus, with coupled phantom bursters, medium oscillating islets can be constructed out of cells that are either all fast, all slow, or a combination of the two.

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Citations

Feb 26, 2014·BMC Medical Genomics·Yang PuYang Cao
Dec 4, 2014·Biophysical Journal·Richard K P BenningerDavid W Piston
Jun 3, 2008·Journal of Neuroendocrinology·G Leng, D J Macgregor
Apr 1, 2014·Trends in Endocrinology and Metabolism : TEM·Richard K P Benninger, David W Piston
Jan 15, 2014·Biophysical Journal·Thomas H HrahaRichard K P Benninger
Sep 23, 2008·Biophysical Journal·Richard K P BenningerDavid W Piston
Jan 10, 2018·Frontiers in Physiology·Marko GosakMarko Marhl
Oct 9, 2007·Diabetes, Obesity & Metabolism·S BavamianP Meda
Oct 21, 2011·Physiological Reviews·Domenico BoscoPaolo Meda
Mar 4, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·I J StamperXujing Wang
Sep 2, 2016·Physiological Reviews·David G Nicholls
Sep 26, 2015·Physical Biology·Alessandro LoppiniMorten Gram Pedersen
Nov 23, 2019·Biophysical Journal·JaeAnn M DwuletRichard K P Benninger
May 4, 2021·PLoS Computational Biology·JaeAnn M DwuletRichard K P Benninger

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