PMID: 6972218May 1, 1981Paper

Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's phenomenon from a single kindred

Arthritis and Rheumatism
W B SheldonE C LeRoy

Abstract

A kindred is reported which contains 3 siblings with scleroderma, 2 siblings with Raynaud's phenomenon, and 2 first-degree relatives with histories suggestive of connective tissue syndromes. Studies of microvascular morphology and flow, serum endothelial cytotoxic activity, antinuclear antibodies, and HLA haplotypes in 18 relatives and 6 spouses revealed that 4 of 5 affected siblings expressed the HLA-DRw4 antigen, which was also present in 2 of 3 asymptomatic relatives whose serum contained endothelial cytotoxic activity. The evidence for an inherited susceptibility to scleroderma is reviewed.

References

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Citations

Jul 1, 1996·Arthritis and Rheumatism·R R Freedman, M D Mayes
Jun 29, 2000·Biochemical and Biophysical Research Communications·R HataH Shinkai
Apr 14, 1999·Australian and New Zealand Journal of Medicine·H EnglertP Brooks
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Oct 1, 1986·Annals of the Rheumatic Diseases·P J MaddisonK I Welsh
Nov 1, 1991·Annals of the Rheumatic Diseases·A J Silman
Nov 1, 1991·Annals of the Rheumatic Diseases·D Briggs, K I Welsh
Sep 1, 1994·Annals of the Rheumatic Diseases·M D de JuanE Cuadrado
Jul 20, 2011·Pediatric Rheumatology Online Journal·Anjali A Sharathkumar, Paul Castillo-Caro
Mar 12, 2005·Current Rheumatology Reports·Carol A Feghali-Bostwick
Jan 1, 1995·International Reviews of Immunology·F C Arnett
Jan 1, 1985·The British Journal of Dermatology·K TakeharaY Ishibashi
Oct 13, 2016·Arthritis Research & Therapy·Chang-Fu KuoMichael Doherty
Jan 1, 1991·The Journal of Dermatology·T SasakiH Nakajima

Related Concepts

Alcohol Consumption
Fluorescent Antinuclear Antibodies
Dyspepsia
Esophagitis
Genealogical Tree
Raynaud Phenomenon
Systemic Scleroderma
Cigar smoker

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