Three sides of the same coin: measuring global cognitive impairment with the MMSE, ADAS-cog and CAMCOG

International Journal of Geriatric Psychiatry
Hans WoutersRobert Lindeboom

Abstract

The total scores of the ADAS-cog, MMSE and CAMCOG, comprising various cognitive tasks, are widely used to measure a dimension of global cognitive impairment. It is unknown, however, whether this dimension is common to these instruments. This hampers comparisons when either of these instruments is used. The extent to which these instruments share a common dimension of global cognitive impairment and how their scores relate was examined. Rasch analysis of CAMCOG and MMSE data of participants from a population based study and two memory clinics pooled with ADAS-cog and MMSE data of participants from three RCTs (overall N = 1566) to estimate a common dimension of global cognitive impairment and to examine the goodness of fit of the individual items to this dimension. Using the estimated common dimension of global cognitive impairment, the total scores of the instruments could be related, e.g. a mean level of global cognitive impairment corresponded to a predicted score of 11.4 (ADAS-cog), 72.6 (CAMCOG) and 22.2 (MMSE). When revised according to The Rasch validity analyses, every individual item could be fitted to the dimension. The MMSE, ADAS-cog and CAMCOG reflect a valid common dimension of global cognitive impairment, which enab...Continue Reading

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Citations

Dec 31, 2011·Journal of the International Neuropsychological Society : JINS·Hans WoutersRobert Lindeboom
Jul 20, 2012·The Clinical Neuropsychologist·Gerardo PrietoFélix Bermejo-Pareja
Oct 9, 2012·International Journal of Geriatric Psychiatry·Ilan Dar-NimrodPaul R Duberstein
May 17, 2012·International Journal of Geriatric Psychiatry·Joan Vilalta-FranchJosep Garre-Olmo
Jan 12, 2013·Journal of Neurology·Jeannette HofmeijerMartine J E van Zandvoort
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Domingo J Quintana-HernándezNoelia Bravo-Caraduje
Sep 5, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·B J HasselbalchL V Kessing
Feb 11, 2011·International Journal of Geriatric Psychiatry·Joan Vilalta-FranchJosep Garre-Olmo
Jul 25, 2017·Injury Epidemiology·Guohua LiUNKNOWN LongROAD Research Team
Feb 15, 2018·Journal of Alzheimer's Disease : JAD·April Ka Sin PhuaXin Xu
Sep 3, 2020·International Journal of Environmental Research and Public Health·Hye-Jin KimKyoung-Bok Min
Sep 22, 2012·International Journal of Geriatric Psychiatry·F GómezA García
Nov 30, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Lindsay C KobayashiRichard N Jones
Jan 6, 2021·Journal of Nephrology·Jessica Anne VanderlindenJohn Gordon Boyd

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