Three-spin solid effect and the spin diffusion barrier in amorphous solids

Science Advances
Kong Ooi TanRobert G Griffin

Abstract

Dynamic nuclear polarization (DNP) has evolved as the method of choice to enhance NMR signal intensities and to address a variety of otherwise inaccessible chemical, biological and physical questions. Despite its success, there is no detailed understanding of how the large electron polarization is transferred to the surrounding nuclei or where these nuclei are located relative to the polarizing agent. To address these questions we perform an analysis of the three-spin solid effect, and show that it is exquisitely sensitive to the electron-nuclear distances. We exploit this feature and determine that the size of the spin diffusion barrier surrounding the trityl radical in a glassy glycerol-water matrix is <6 Å, and that the protons involved in the initial transfer step are on the trityl molecule. 1H ENDOR experiments indicate that polarization is then transferred in a second step to glycerol molecules in intimate contact with the trityl.

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Feb 13, 2019·Science Advances·Kong Ooi TanRobert G Griffin

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Citations

May 1, 2020·Physical Chemistry Chemical Physics : PCCP·J JärvinenY Fujii
Jul 23, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeffrey R BrenderMurali C Krishna
Sep 17, 2020·Science Advances·Mateusz T MądzikAndrea Morello
Jan 7, 2021·Physical Chemistry Chemical Physics : PCCP·Nathan A PriscoBradley F Chmelka
Feb 27, 2021·Physical Chemistry Chemical Physics : PCCP·Janne SoetbeerGunnar Jeschke
May 2, 2021·Journal of Magnetic Resonance·W Th WenckebachJ H Ardenkjær-Larsen
May 21, 2021·Journal of the American Chemical Society·Stephen von KugelgenDanna E Freedman
Jun 30, 2021·Journal of Magnetic Resonance·T V CanR G Griffin
Jul 24, 2020·The Journal of Organic Chemistry·Urikhan SanzhaevaBenoit Driesschaert
Apr 14, 2020·The Journal of Physical Chemistry Letters·Elizabeth R CanarieStefan Stoll
Apr 14, 2020·The Journal of Physical Chemistry Letters·Kong Ooi TanRobert G Griffin
Feb 26, 2020·The Journal of Physical Chemistry Letters·Jia ChenXiao-Guang Zhang
Nov 24, 2021·Journal of the American Chemical Society·Léo Delage-LaurinRobert G Griffin
Nov 25, 2021·The Journal of Physical Chemistry. B·Georges MenzildjianAnne Lesage

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
electron paramagnetic resonance
ENDOR

Software Mentioned

TSSE
MATLAB
Mathematica

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