Three subsystems of the inferior parietal cortex are differently affected in mild cognitive impairment

Journal of Alzheimer's Disease : JAD
Peipeng LiangKuncheng Li

Abstract

The Inferior parietal cortex (IPC), including the intraparietal sulcus (IPS), angular gyrus (AG), and supramarginal gyrus (SG), plays an important role in episodic memory, and is considered to be one of the specific neuroimaging markers in predicting the conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD). However, it is still unclear whether the connectivity of the IPC is impaired in MCI patients. In the present study, we used resting state fMRI to examine the functional connectivity of the three subdivisions of the IPC in MCI patients after controlling the impact of regional grey matter atrophy. It was found that, using IPS, AG, and SG as seeds of functional connectivity, three canonical functional networks could be correspondingly traced, i.e., executive control network (ECN), default mode network (DMN), and salience network (SN), and the three networks are differently altered in MCI patients. In contrast to the healthy controls, it was found that in MCI patients: 1) AG connectivity was significantly reduced within the DMN; 2) IPS showed decreased connectivity with the right inferior frontal gyrus while showing increased connectivity with the left frontal regions within the ECN; and 3) SG displayed decr...Continue Reading

Citations

Jan 7, 2016·Frontiers in Aging Neuroscience·Angela TamUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 9, 2013·Brain Connectivity·Chandan J Vaidya, Evan M Gordon
Oct 28, 2015·Scientific Data·Pierre OrbanUNKNOWN PREVENT-AD Research Group
Apr 1, 2014·Brain Structure & Function·Gabriel Gonzalez-EscamillaJose L Cantero
Jun 8, 2014·American Journal of Alzheimer's Disease and Other Dementias·Peipeng LiangKuncheng Li
Jun 12, 2014·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Luiz K FerreiraGeraldo F Busatto
Jun 1, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·AmanPreet BadhwarPierre Bellec
Sep 20, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Ece BayramSarah J Banks
Feb 25, 2015·PloS One·Ram J BishnoiDonald R Royall
Apr 27, 2018·Frontiers in Aging Neuroscience·Xingyun LiuZhiqun Wang
Jul 25, 2017·Frontiers in Neuroscience·Linlin LiuQuan Zhang

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