Three toxic gases meet in the mitochondria

Frontiers in Physiology
Richard A Decréau, James P Collman

Abstract

The rationale of the study was two-fold: (i) develop a functional synthetic model of the Cytochrome c oxidase (CcO) active site, (ii) use it as a convenient tool to understand or predict the outcome of the reaction of CcO with ligands (physiologically relevant gases and other ligands). At physiological pH and potential, the model catalyzes the 4-electron reduction of oxygen. This model was immobilized on self-assembled-monolayer (SAM) modified electrode. During catalytic oxygen reduction, electron delivery through SAMs is rate limiting, similar to the situation in CcO. This model contains all three redox-active components in CcO's active site, which are required to minimize the production of partially-reduced-oxygen-species (PROS): Fe-heme ("heme a3") in a myoglobin-like model fitted with a proximal imidazole ligand, and a distal tris-imidazole Copper ("CuB") complex, where one imidazole is cross-linked to a phenol (mimicking "Tyr244"). This functional CcO model demonstrates how CcO itself might tolerate the hormone NO (which diffuses through the mitochondria). It is proposed that CuB delivers superoxide to NO bound to Fe-heme forming peroxynitrite, then nitrate that diffuses away. Another toxic gas, H2S, has exceptional biolog...Continue Reading

References

May 11, 1977·Biochimica Et Biophysica Acta·L C Petersen
Jan 15, 1979·FEBS Letters·T H StevensS I Chan
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P CollmanK S Suslick
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J P CollmanK S Suslick
Mar 19, 1975·Journal of the American Chemical Society·J P CollmanW T Robinson
Nov 26, 1975·Journal of the American Chemical Society·J P CollmanK S Suslick
Dec 18, 1992·Science·J S StamlerJ Loscalzo
Mar 26, 1992·Nature·G T Babcock, M Wikström
May 1, 1990·Toxicology and Applied Pharmacology·A A KhanL E Lillie
Aug 1, 1987·Antimicrobial Agents and Chemotherapy·K MizojiriK Sugeno
Dec 1, 1972·Archives of Biochemistry and Biophysics·L Salganicoff, M H Fukami
Jun 1, 1967·European Journal of Biochemistry·F Palmieri, M Klingenberg
Jun 1, 1982·Canadian Journal of Biochemistry·P Nicholls, J K Kim
Jan 1, 1984·Critical Reviews in Toxicology·R O BeauchampD A Andjelkovich
Feb 5, 1996·Journal of Biochemical and Biophysical Methods·A M TanS S Qu
Jan 1, 1996·Methods in Enzymology·W H KoppenolJ S Beckman
Jan 15, 1998·FEBS Letters·P Ghafourifar, C Richter
Jun 6, 1998·The Journal of Biological Chemistry·C GiuliviA Boveris
Jun 19, 1998·Biochimica Et Biophysica Acta·M Degli Esposti
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·D A ProshlyakovG T Babcock
Dec 26, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·David C DormanMelanie F Struve
Nov 7, 1996·Chemical Reviews·Shelagh Ferguson-Miller, Gerald T. Babcock
Apr 11, 2002·Chemical Reviews·Peter C Ford, Ivan M Lorkovic
Apr 16, 2002·Inorganic Chemistry·James P CollmanRoman Boulatov
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
May 29, 2003·Journal of the American Chemical Society·James P CollmanEdward I Solomon
Aug 12, 2003·Trends in Immunology·Leo E OtterbeinFritz H Bach
Sep 13, 2003·Pharmacology & Toxicology·Jose-Ramon AlonsoOscar Miró
Sep 1, 1960·Archives of Biochemistry and Biophysics·W W WAINIO, J GREENLESS
Feb 12, 2004·Chemical Reviews·J A McCleverty
Feb 12, 2004·Chemical Reviews·James P CollmanLei Fu
May 11, 2004·The Journal of Organic Chemistry·James P CollmanChi Zhang
Aug 4, 2004·Respiratory Physiology & Neurobiology·Gerhard HeldmaierRalf Elvert

❮ Previous
Next ❯

Citations

Jan 6, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marcos Roberto de OliveiraSeyed Mohammad Nabavi
Oct 18, 2016·Nutrition·Geir Bjørklund, Salvatore Chirumbolo
Jan 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Nabhendu Pal, Amit Majumdar
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo
Apr 25, 2021·Journal of Inorganic Biochemistry·Virginia DizSara E Bari
Oct 30, 2018·Chemical Reviews·Suzanne M AdamKenneth D Karlin

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Software Mentioned

SAM

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.