Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium

The Journal of Pathology
Hiroto KinoshitaKazuhiko Koike

Abstract

Chronic inflammation and intestinal metaplasia are strongly associated with gastric carcinogenesis. Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. Although various mouse models of gastric carcinogenesis have been reported, few mouse lines enable gene manipulation selectively in the stomach. Here we established a Tff1-Cre bacterial artificial chromosome transgenic mouse line in an attempt to induce gene modification specifically in the gastric pit lineage. In the stomach, Tff1-Cre-mediated recombination was most evident in the pit lineage in the corpus and in entire antral glands; recombination was also observed in a few gastric chief and parietal cells. Outside the stomach, recombination was patchy throughout the intestines, and particularly frequently in the duodenum (Brunner glands), cecum, and proximal colon. In the stomachs of Tff1-Cre;LSL-KrasG12D mice, proliferating cell clusters expanded throughout the corpus glands, with foveolar cell expansion with ectopic Alcian blue-positive mucins, oxyntic atrophy, and pseudopyloric changes with spasmolytic polypeptide-expressing metaplasia; however, gastric cancer was not observed e...Continue Reading

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Citations

Jun 11, 2020·Cancer Science·Yukiko OyaKazuhiko Koike
Nov 6, 2018·Biomedicines·Masahiro HataKazuhiko Koike
May 22, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Lindsay C HewittHeike I Grabsch
Jul 6, 2019·Neoplasia : an International Journal for Oncology Research·Wen-Cheng ChungKeli Xu
Jun 16, 2021·Cell Stem Cell·Yoku HayakawaTimothy C Wang
Jun 19, 2021·World Journal of Clinical Cases·Yang-Kun WangSu-Nan Wang
Aug 16, 2021·Gastroenterology·Daisuke DouchiYoshiaki Ito

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