Abstract
The electrophysiological study of red blood cells (RBCs), using the patch-clamp technique, has been going through a renaissance with the recent discovery of novel channel activity in the host plasma membrane of Plasmodium falciparum-infected human RBCs (S.A. Desai et al., Nature 406, 1001-1005, 2000; S.M. Huber et al., EMBO J. 21 (2002) 22-30; S. Egee et al., J. Physiol. 542 (2002) 795-801). This arose from the finding that malaria-infected RBCs have altered permeability characteristics due to the induction of new permeation pathways (NPPs) (H. Ginsburg, Novartis Foundation Symposium 226 (1999) 99-108; K. Kirk, Physiol. Rev. 81 (2001) 495-537), which are defined, using non-electrophysiological techniques, as having the general characteristics of anion channels (i.e. high anion permeability, linear concentration dependence, inability to distinguish between stereo-isomers of permeant solutes). Discovering potent and specific inhibitors of the NPPs is an important therapeutic challenge, but too many questions remain unanswered: do the NPPs correspond to a single path or multiple pathways? Are they parasite-derived proteins? Are they up-regulated or modified endogenous quiescent red blood cell proteins? This article concerns the id...Continue Reading
References
May 31, 1991·Biochimica Et Biophysica Acta·P Christophersen, P Bennekou
Jan 1, 1986·The Journal of Membrane Biology·V L Lew, R M Bookchin
Mar 1, 1985·Molecular and Biochemical Parasitology·H GinsburgZ I Cabantchik
Dec 1, 1983·Cell Calcium·R Grygorczyk, W Schwarz
Nov 16, 1994·Biochemical Pharmacology·H Ginsburg
Sep 13, 2000·Nature·S A DesaiJ Zimmerberg
Mar 29, 2001·Physiological Reviews·K Kirk
Aug 3, 2002·The Journal of Physiology·Stéphane EgéeSerge L Y Thomas
Mar 12, 2004·The Journal of Membrane Biology·H Ginsburg, W D Stein
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Sanjay A Desai
Citations
Nov 19, 2010·The Journal of Membrane Biology·Mayra Delgado-RamírezOxana R Dobrovinskaya
Aug 13, 2008·Pflügers Archiv : European journal of physiology·Canan AkkayaStephan M Huber
Jan 27, 2010·Molecular Pharmacology·Ajay D PillaiSanjay A Desai
Jul 15, 2006·Blood·Henry M StainesJ Clive Ellory
Mar 3, 2010·PloS One·Agnieszka DyrdaSerge L Y Thomas
Feb 6, 2008·PLoS Pathogens·Anaïs MerckxStéphane Egée
Dec 22, 2009·Future Microbiology·David A Hill, Sanjay A Desai
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Guillaume BouyerSerge L Y Thomas
Mar 25, 2011·Blood Cells, Molecules & Diseases·Serge L Y ThomasCéline Ollivaux
Mar 17, 2010·Blood Cells, Molecules & Diseases·Edyta GlogowskaSerge L Y Thomas
Feb 10, 2009·Trends in Parasitology·Anaïs MerckxStéphane Egée
Feb 13, 2007·International Journal for Parasitology·Henry M StainesSanjay A Desai
Dec 22, 2006·Molecular Microbiology·Marta C NunesArtur Scherf
Mar 22, 2012·Cellular Microbiology·Sanjay A Desai
May 15, 2012·Microbes and Infection·Stephan M Huber
Sep 23, 2008·Biochemical and Biophysical Research Communications·Stephan M HuberChristophe Duranton
Jul 29, 2011·Blood·Guillaume BouyerSerge L Y Thomas
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·David A HillSanjay A Desai
Dec 22, 2017·Open Biology·David A BakerEloise M Walker
Feb 9, 2007·Molecular Pharmacology·Godfrey LiskSanjay A Desai