Three types of spontaneously active anionic channels in malaria-infected human red blood cells

Blood Cells, Molecules & Diseases
Guillaume BouyerSerge L Y Thomas

Abstract

The electrophysiological study of red blood cells (RBCs), using the patch-clamp technique, has been going through a renaissance with the recent discovery of novel channel activity in the host plasma membrane of Plasmodium falciparum-infected human RBCs (S.A. Desai et al., Nature 406, 1001-1005, 2000; S.M. Huber et al., EMBO J. 21 (2002) 22-30; S. Egee et al., J. Physiol. 542 (2002) 795-801). This arose from the finding that malaria-infected RBCs have altered permeability characteristics due to the induction of new permeation pathways (NPPs) (H. Ginsburg, Novartis Foundation Symposium 226 (1999) 99-108; K. Kirk, Physiol. Rev. 81 (2001) 495-537), which are defined, using non-electrophysiological techniques, as having the general characteristics of anion channels (i.e. high anion permeability, linear concentration dependence, inability to distinguish between stereo-isomers of permeant solutes). Discovering potent and specific inhibitors of the NPPs is an important therapeutic challenge, but too many questions remain unanswered: do the NPPs correspond to a single path or multiple pathways? Are they parasite-derived proteins? Are they up-regulated or modified endogenous quiescent red blood cell proteins? This article concerns the id...Continue Reading

References

May 31, 1991·Biochimica Et Biophysica Acta·P Christophersen, P Bennekou
Mar 29, 2001·Physiological Reviews·K Kirk
Aug 3, 2002·The Journal of Physiology·Stéphane EgéeSerge L Y Thomas
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Sanjay A Desai

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Citations

Nov 19, 2010·The Journal of Membrane Biology·Mayra Delgado-RamírezOxana R Dobrovinskaya
Aug 13, 2008·Pflügers Archiv : European journal of physiology·Canan AkkayaStephan M Huber
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Guillaume BouyerSerge L Y Thomas
Mar 25, 2011·Blood Cells, Molecules & Diseases·Serge L Y ThomasCéline Ollivaux
Mar 17, 2010·Blood Cells, Molecules & Diseases·Edyta GlogowskaSerge L Y Thomas
Feb 10, 2009·Trends in Parasitology·Anaïs MerckxStéphane Egée
Feb 13, 2007·International Journal for Parasitology·Henry M StainesSanjay A Desai
Mar 22, 2012·Cellular Microbiology·Sanjay A Desai
May 15, 2012·Microbes and Infection·Stephan M Huber
Sep 23, 2008·Biochemical and Biophysical Research Communications·Stephan M HuberChristophe Duranton
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·David A HillSanjay A Desai
Dec 22, 2017·Open Biology·David A BakerEloise M Walker

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