PMID: 9430484Jan 16, 1998Paper

Three-window transformation cross-talk correction for simultaneous dual-isotope imaging

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
K Knesaurek, J Machac

Abstract

We developed and tested a new transformation cross-talk correction method for simultaneous dual-isotope SPECT imaging, which uses information from three energy windows in a simultaneous 18F/99mTc cardiac phantom study. The method combines the previously reported "three-window" technique and transformation cross-talk correction methods. In the three-window technique, the images from the third energy "scatter" window are usually multiplied by a constant factor to obtain the estimates of the cross-talk. However, such an approach neglects differences in the spatial distribution between cross-talk photons in different energy windows. The transformation method is based on the assumption that the transformations, which convert the images from one energy window into the other energy windows, are known. These transformations were found by measuring the point-spread functions in different energy windows for both isotopes in water. The transformation method takes into account the different spatial distributions of the primary and scatter cross-talk photons in the different energy windows. Here, we are assuming that the imaging system and the image transformations between different energy windows are shift-invariant and linear. Thus, the n...Continue Reading

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