Three-year changes of prothrombotic factors in a cohort of South Africans with a high clinical suspicion of obstructive sleep apnea

Thrombosis and Haemostasis
R von KänelL Malan

Abstract

A hypercoagulable state might be one important mechanism linking obstructive sleep apnea (OSA) with incident myocardial infarction and stroke. However, previous studies on prothrombotic factors in OSA are not uniform and cross-sectional. We longitudinally studied prothrombotic factors in relation to OSA risk, adjusting for baseline levels of prothrombotic factors, demographics, metabolic parameters, aspirin use, and life style factors. The Berlin Questionnaire and/or neck circumference were used to define high OSA risk in 329 South African teachers (48.0% male, 44.6% black) at baseline and at three-year follow-up. Von Willebrand factor (VWF), fibrinogen, D-dimer, plasminogen activator inhibitor-1, clot lysis time (CLT), and soluble urokinase-type plasminogen activator receptor (suPAR) were measured in plasma. At baseline 35.7% of participants had a high risk of OSA. At follow-up, persistently high OSA risk, persistently low OSA risk, OSA risk remission, and new-onset OSA risk were present in 26.1%, 53.2%, 9.4%, and 11.3% of participants, respectively. New-onset OSA risk was associated with a significant and longitudinal increase in VWF, fibrinogen, CLT, and suPAR relative to persistently low OSA risk; in VWF, fibrinogen, and su...Continue Reading

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Citations

Nov 6, 2018·The European Respiratory Journal·Alberto García-OrtegaMiguel Ángel Martínez-García
Apr 27, 2018·Frontiers in Endocrinology·Peter L WhitesellAnne E Sumner
Apr 4, 2021·International Journal of Molecular Sciences·Andras BikovEsther Irene Schwarz
May 1, 2021·Journal of Clinical Medicine·Martina MeszarosAndras Bikov
Jul 25, 2021·Journal of Clinical Medicine·Cindy ZolotoffNathalie Perek

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