Three-year clinical experience with magnetic sphincter augmentation and laparoscopic fundoplication.

Surgical Endoscopy
Luigi BonavinaJanet DeMarchi

Abstract

Magnetic sphincter augmentation (MSA) is a surgical intervention for gastroesophageal reflux disease (GERD) which has been evaluated in numerous studies and has shown beneficial effects. Long-term effectiveness data for MSA as well as laparoscopic fundoplication (LF) in patients with GERD are needed. The objective of this study was to evaluate the 3-year outcomes for MSA and LF in patients with GERD. This prospective, multi-center, observational registry study evaluated MSA and LF in clinical practice over 3 years (ClinicalTrials.gov identifier: NCT01624506). Data collection included baseline characteristics, reflux symptoms, medication use, satisfaction and complications. Post-surgical evaluations were collected at yearly intervals. Between December 2009 and December 2014, 631 patients (465 MSA and 166 LF) were enrolled in the registry. Both MSA and LF resulted in improvements in total GERD-HRQL score (mean reduction in GERD-HRQL from baseline to 3 years post-surgery: MSA 22.0 to 4.6 and LF 23.6 to 4.9) and in satisfaction (GERD-HRQL satisfaction increase from baseline to 3 years: MSA 4.6% to 78.2% and LF 3.7% to 76.5%). Most patients were able to belch as needed with both therapies (MSA 97.6% and LF 91.7% at 3 years). MSA all...Continue Reading

Associated Clinical Trials

References

Mar 1, 1992·Medical Care·M E AdamsT C Chalmers
May 25, 2005·Annals of Surgery·C Daniel SmithJohn G Hunter
Apr 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·V Velanovich
Dec 30, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lauren B Gerson, Ronnie Fass
Apr 21, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Reema ModyRonnie Fass
Aug 21, 2010·Surgical Endoscopy·Dimitrios StefanidisUNKNOWN SAGES Guidelines Committee
Apr 28, 2012·Surgical Endoscopy·John C LiphamWillem Bemelman
Jun 1, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tara I Chang, Wolfgang C Winkelmayer
Oct 12, 2012·Surgical Endoscopy·Reginald C W BellKatherine D Freeman
Dec 27, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joel E Richter
Feb 20, 2013·The American Journal of Gastroenterology·Philip O KatzMarcelo F Vela
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert A GanzDan Dunn
Oct 6, 2015·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Greta SainoRobert A Ganz
Feb 5, 2016·World Journal of Gastrointestinal Surgery·Maureen MooreRasa Zarnegar
Dec 28, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert A Ganz
Dec 29, 2016·Digestive Diseases and Sciences·Rena YadlapatiRajesh N Keswani
May 10, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Nadia GuidozziSheraz R Markar

❮ Previous
Next ❯

Citations

Apr 23, 2021·Current Opinion in Gastroenterology·Luigi BonavinaSebastian F Schoppmann
Oct 1, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Milena NikolicSebastian F Schoppmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.