Three-Year Outcomes From the Harmony Native Outflow Tract Early Feasibility Study

Circulation. Cardiovascular Interventions
Lee N BensonJohn P Cheatham

Abstract

The Harmony transcatheter pulmonary valve (TPV) was designed for treatment of postoperative pulmonary valve regurgitation in patients with repaired right ventricular outflow tracts. The Native TPV EFS (Early Feasibility Study) is a prospective, multicenter, nonrandomized feasibility study. Three-year outcomes are reported. Of 20 implanted patients, 17 completed 3-year follow-up (maximum: 4.1 years). There were no deaths and 2 early explants. One patient did not complete the 3-year visit. In patients with available 3-year echocardiographic data, 1 had a mild paravalvular leak and the rest had none/trace; 1 patient had mild pulmonary valve regurgitation and the remainder had none/trace. The 3-year mean right ventricular outflow tract echocardiographic gradient was 15.7±5.5 mm Hg. Radiographically, no late frame fractures or erosions were identified. At 2 years, 2 patients presented with an increased echocardiographic outflow gradient (1 mixed lesion with moderate/severe pulmonary valve regurgitation). Computed tomography scans identified neointimal tissue ingrowth within the stent frame in both patients, and they were treated successfully with a transcatheter valve-in-valve procedure (Melody TPV). Additional follow-up computed to...Continue Reading

References

Jul 10, 2013·Annals of the New York Academy of Sciences·Doff B McElhinney, Jill T Hennesen
Aug 31, 2013·The Journal of Thoracic and Cardiovascular Surgery·Thomas J van BrakelFelix Haas
Apr 29, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ian LindsayDaniel Levi
Aug 22, 2017·The American Journal of Cardiology·Matthew J GillespieJohn P Cheatham
Sep 9, 2017·JACC. Cardiovascular Interventions·Lisa BergersenJohn P Cheatham
Sep 25, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gareth MorganShakeel Qureshi
Nov 7, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Daxin ZhouJunbo Ge

❮ Previous
Next ❯

Citations

Oct 11, 2020·Current Cardiology Reports·Tomohito Kogure, Shakeel A Qureshi
Feb 5, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Georg LutterThomas Puehler
Mar 1, 2021·The Journal of Thoracic and Cardiovascular Surgery·Robert G WillettsPhil Botha
Apr 8, 2021·JACC. Cardiovascular Interventions·Matthew J GillespieJohn P Cheatham
Jun 10, 2021·Expert Review of Cardiovascular Therapy·Jennifer P WooGeorge K Lui
Oct 25, 2020·The Journal of Thoracic and Cardiovascular Surgery·Paul Tannous, Alan Nugent
Aug 11, 2021·Current Opinion in Pediatrics·Jeremy M SteeleSean M Lang
Jan 16, 2022·Seminars in Thoracic and Cardiovascular Surgery·David Kalfa

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery imaging

Software Mentioned

Mimics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.