Three-year patient-reported visual function outcomes in diabetic macular edema managed with ranibizumab: the RESTORE extension study

Current Medical Research and Opinion
Paul MitchellNeil M Bressler

Abstract

To determine the impact of ranibizumab 0.5 mg on patient-reported visual function over 36 months in individuals with visual impairment from diabetic macular edema. RESTORE comprises a phase 3, randomized, multicenter, 12 month core study and a 24 month open-label extension study. Eyes assigned to ranibizumab in the core study received ranibizumab for 36 months; eyes assigned to laser monotherapy in the core study received ranibizumab during the extension. The primary outcome was least-squares mean change in National Eye Institute 25-item Visual Functioning Questionnaire (NEI VFQ-25) overall composite and subscale scores. Of 303 core study participants, 240 (79%) entered the extension, comprising 83 (35%) participants initially assigned to ranibizumab, 83 (35%) assigned to ranibizumab plus laser combination therapy, and 74 (31%) assigned to laser monotherapy. Least-squares mean (standard error) change in NEI VFQ-25 composite score from baseline to month 12 (+5.9 [1.5]; +5.0 [1.5], for the ranibizumab and combination therapy groups, respectively) decreased by month 36 (+4.1 [1.7]; +4.0 [1.7], respectively, from baseline to month 36) following reduced injection frequency relative to the core study. At 36 months, the least-squares ...Continue Reading

References

Jun 17, 1998·Ophthalmology·S E MossB E Klein
Jul 27, 2001·Archives of Ophthalmology·C M MangioneUNKNOWN National Eye Institute Visual Function Questionnaire Field Test Investigators
Dec 23, 2006·Health and Quality of Life Outcomes·Jan Mitchell, Clare Bradley
Jun 23, 2007·The British Journal of Ophthalmology·S M HariprasadL Miller
Mar 4, 2009·Investigative Ophthalmology & Visual Science·Ivan J SuñerNeil M Bressler
Oct 10, 2009·Investigative Ophthalmology & Visual Science·Fumiki OkamotoTetsuro Oshika
Feb 26, 2010·Journal of Biopharmaceutical Statistics·Michael G Kenward, Geert Molenberghs
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Sep 8, 2011·Investigative Ophthalmology & Visual Science·Jane V LoftusUNKNOWN Macugen 1013 Study Group
Feb 15, 2012·Ophthalmology·Quan Dong NguyenUNKNOWN RISE and RIDE Research Group
Feb 5, 2014·Ophthalmology·Ursula Schmidt-ErfurthUNKNOWN RESTORE Extension Study Group

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Citations

Jun 1, 2018·Journal of Ophthalmology·Anne-Laurence BestAudrey Giocanti-Aurégan
May 31, 2017·Clinical & Experimental Ophthalmology·Gemmy Cm CheungTien Y Wong
Jan 18, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Petra SchwarzerMartin S Zinkernagel

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