Three-year survival following multivessel percutaneous coronary intervention with bare-metal or drug-eluting stents in unselected patients

The American Journal of Cardiology
Neville KukrejaInterventional Cardiologists of the Thoraxcenter (2000-5)

Abstract

Drug-eluting stents (DESs) have been shown to reduce the rate of repeat revascularization compared with bare-metal stents (BMSs) after multivessel percutaneous coronary intervention in carefully selected patients. However, the long-term safety and efficacy of DESs in patients with multivessel disease outside the setting of randomized trials was unknown. Therefore, all patients undergoing multivessel percutaneous coronary intervention with BMSs, sirolimus-eluting stents (SESs), or paclitaxel-eluting stents (PESs) from January 2000 to December 2005 were investigated. The primary end point was all-cause mortality. A total of 1,720 patients were recruited in 3 consecutive sequential groups of BMS (n=701; January 2000 to April 2002), SES (n=293; April 2002 to February 2003), and PES (n=726; February 2003 to December 2005). Overall median follow-up was 1,440 days. There was improved 3-year survival in the SES group (93.7%) compared with both the BMS (86.1%) and PES groups (87.3%), which remained significant after propensity score adjustment for differences in baseline and procedural characteristics (SES vs BMS, adjusted hazard ratio 0.53, 95% confidence interval 0.30 to 0.94; SES vs PES, adjusted hazard ratio 0.49, 95% confidence int...Continue Reading

References

Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Apr 6, 2004·Journal of the American College of Cardiology·Dejan OrlicAntonio Colombo
Jun 21, 2005·Journal of the American College of Cardiology·Andrew T L OngPatrick W Serruys
May 2, 2007·Circulation·Ralph B D'Agostino
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 10, 2007·JAMA : the Journal of the American Medical Association·Nirat BeoharDavid O Williams
May 10, 2007·JAMA : the Journal of the American Medical Association·Htut K WinUNKNOWN EVENT Registry Investigators

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Citations

Jun 3, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ankur SethiSandeep Khosla
Sep 10, 2011·Journal of the American College of Cardiology·Chang-Wook NamUNKNOWN FAME Study Investigators
Oct 11, 2017·American Journal of Epidemiology·Alexandra G EllisIssa J Dahabreh
Aug 14, 2012·Journal of Interventional Cardiology·Fabrizio D'AscenzoImad Sheiban

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