PMID: 9179548May 1, 1997Paper

Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects

European Journal of Clinical Investigation
H VidgrenM Uusitupa

Abstract

Intestinal fatty acid binding protein (I-FABP) participates in the metabolism of fatty acids in the intestinal enterocytes. Threonine encoding allele in codon 54 of the I-FABP gene has been suggested as regulating the absorption of long-chain fatty acids. We examined the fatty acid composition of serum lipid fractions and the concentration of serum free fatty acids after an overnight fast in obese subjects, aged 24-56 years, on their habitual diet. The body mass index of the subjects ranged from 29.7 to 43.3 kg m-2. Six subjects were homozygous for the Thr-54 allele of the I-FABP gene, 37 subjects were heterozygous for the Thr-54/Ala-54 allele and 24 subjects were homozygous for the Ala-54 allele. We did not find any consistent differences in the proportions of long-chain fatty acids in serum triglycerides, cholesterol esters or phospholipids, but the concentration of serum free fatty acids tended to be higher in subjects who were homozygous for the Thr-54 allele (P = 0.13, for trend). In conclusion, our findings suggest that a polymorphism at codon 54 of the I-FABP2 gene does not substantially modify the fatty acid composition of serum lipids in obese Finns.

Citations

Dec 21, 2000·Current Atherosclerosis Reports·J M Ordovas, J R Galluzzi
Mar 21, 2003·Biochemical and Biophysical Research Communications·Yoshiko YanagisawaYasuo Kagawa
Jul 12, 2003·Molecular Genetics and Metabolism·Natalia L DuarteDavid E L Wilcken
Jun 26, 2001·European Journal of Clinical Investigation·K C ChiuC Yoon
Mar 19, 2013·Journal of Diabetes and Metabolic Disorders·Hamideh PishvaSoltan Ali Mahboob
Jul 31, 2007·The Tohoku Journal of Experimental Medicine·Ales ZákMiroslav Zeman
Mar 24, 2010·Cancer Epidemiology·Ikuko KatoRichard K Severson
Nov 6, 2004·Acta Neurologica Scandinavica·P WanbyM Carlsson
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J J AgrenM Uusitupa
Feb 15, 2008·Intellectual and Developmental Disabilities·Deirdre E ReillyJaci C Huws
Sep 23, 2003·The American Journal of Gastroenterology·Bruce D GreenwaldOleh Haluszka
May 5, 2010·The American Journal of Hospice & Palliative Care·Virginia L Seno

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