PMID: 11916756Mar 28, 2002Paper

Threonine requirement of healthy adults, derived with a 24-h indicator amino acid balance technique

The American Journal of Clinical Nutrition
Sudhir BorgonhaVernon R Young

Abstract

Because we question the validity of the 1985 FAO/ WHO/UNU upper requirement for threonine of 7 mg x kg(-1) x d(-1), we proposed a tentative mean requirement of 15 mg x kg(-1) x d(-1). Our goal was to assess threonine adequacy at 3 test intakes and the consequences of a 6-d compared with a 13-d dietary adaptation phase. We used a 24-h indicator amino acid balance technique ([1-(13)C]leucine as indicator) to assess the threonine requirement. Fifteen healthy adults were randomly assigned to receive 7, 15, or 46 mg threonine x kg(-1) x d(-1) and were studied after 6 and 13 d of adaptation to the experimental diets. Diets were based on an L-amino acid mixture in which the threonine content was varied. At 1700 on days 6 and 13, a 24-h intravenous [(13)C]leucine tracer infusion protocol was begun to assess leucine oxidation and daily leucine balances. There was no detectable effect of duration of dietary adaptation in leucine oxidation or balance, but the 24-h leucine oxidation and balances differed significantly between the 7-mg intake and each of the 2 higher intakes (P < 0.05). The latter were not significantly different. The 24-h leucine oxidation rate decreased across threonine intakes (P < 0.01 for main effect of diet, independe...Continue Reading

References

May 1, 1986·The American Journal of Clinical Nutrition·X H ZhaoV R Young
Sep 1, 1995·The American Journal of Clinical Nutrition·A E el-KhouryV R Young
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·V R Young, A E el-Khoury
Jan 24, 1998·The American Journal of Clinical Nutrition·A V KurpadV R Young
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Mar 4, 2000·The American Journal of Clinical Nutrition·D C WilsonP B Pencharz
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Jan 10, 1956·The Journal of Nutrition·R M LEVERTONA MITCHELL
Jan 1, 1989·Nutrition Research Reviews·D J MillwardJ P Rivers

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Citations

Jun 9, 2005·The American Journal of Clinical Nutrition·Paul J MoughanAmélie Deglaire
Aug 10, 2005·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Apr 30, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Sep 27, 2002·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Aug 17, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wantanee KriengsinyosPaul B Pencharz
Jun 10, 2006·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Mar 29, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Mar 11, 2003·Annual Review of Nutrition·Paul B Pencharz, Ronald O Ball
Dec 21, 2005·The Journal of Nutrition·Anura V KurpadJustin V Gnanou

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