Threshold and other departures from linear-quadratic curvature in the non-cancer mortality dose-response curve in the Japanese atomic bomb survivors

Radiation and Environmental Biophysics
Mark P Little

Abstract

Recently released data on non-cancer mortality in Japanese atomic bomb survivors are analysed using a variety of generalised relative risk models that take account of errors in estimates of dose to assess the dose-response at low doses. If linear-threshold, quadratic-threshold or linear-quadratic-threshold relative risk models (the dose-response is assumed to be linear, quadratic or linear-quadratic above the threshold, respectively) are fitted to the non-cancer data there are no statistically significant ( p>0.10) indications of threshold departures from linearity, quadratic curvature or linear-quadratic curvature. These findings are true irrespective of the assumed magnitude of dosimetric error, between 25%-45% geometric standard deviations. In general, increasing the assumed magnitude of dosimetric error had little effect on the central estimates of the threshold, but somewhat widened the associated confidence intervals. If a power of dose model is fitted, there is little evidence ( p>0.10) that the power of dose in the dose-response is statistically significantly different from 1, again irrespective of the assumed magnitude of dosimetric errors in the range 25%-45%. Again, increasing the size of the errors resulted in wider...Continue Reading

Citations

Jul 6, 2014·Medical Physics·Mohan DossColin G Orton
Nov 27, 2004·Radiation and Environmental Biophysics·James BennettSylvia Richardson
Nov 13, 2009·Radiation and Environmental Biophysics·Wolfgang F Heidenreich, H M Cullings
Aug 2, 2013·Radiation and Environmental Biophysics·Mark P Little
Aug 12, 2009·Revue D'épidémiologie Et De Santé Publique·C Metz-FlamantM-O Bernier
Feb 21, 2018·Radiation Research·Paula BoaventuraPaula Soares
Dec 13, 2005·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Wei ZhangNezahat Hunter
May 21, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·M P Little
Nov 26, 2015·Cardio-Oncology·Mark P Little, Steven E Lipshultz

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