PMID: 8938538Nov 1, 1996Paper

Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C

Journal of Hepatology
N K BeinkerR E Kirsch

Abstract

In hepatitis C, iron depletion may improve serum aminotransferases and the response to interferon, but it is not known whether inflammation and fibrosis correlate with hepatic iron content. Our aim was to establish whether hepatic iron content correlates with histological and serum indices of hepatic inflammation and fibrosis in hepatitis B and C. Total hepatic iron was measured using computerized histomorphometry, and hepatic inflammation and fibrosis using a modified Knodell score, on histological slides from 31 patients with chronic hepatitis B and 38 with hepatitis C. Total hepatic iron was similar in the hepatitis B and C groups (0.82 +/- 1.72% and 0.56 +/- 1.12%; mean +/- SD). No iron was detectable in 11 patients with hepatitis B and 13 with hepatitis C. Alanine aminotransferase (85.96 +/- 67.1 vs 44.2 +/- 39.7 p < 0.05), aspartate aminotransferase (93.8 +/- 75.6 vs 47 +/- 33.5 IU/ml p < 0.05) and histological inflammatory score (9.33 +/- 3.51 vs 7.79 +/- 3.3 p = 0.07) were increased in those with stainable hepatic iron compared to those without. However, where iron was present, no association was found between the amount of hepatic iron and inflammatory or fibrosis scores. In hepatitis C, fibrosis was minimal in 77% of ...Continue Reading

References

May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C FeltonB S Blumberg
Sep 1, 1977·British Journal of Haematology·A M Konijn, C Hershko
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J OlynykM Mackinnon
Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B S BlumbergP L Whitford
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Nov 1, 1993·Journal of Gastroenterology and Hepatology·A TsubotaH Kumada
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MackinnonP Hall
Mar 1, 1994·Journal of Hepatology·D H Van ThielJ S Gavaler
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer

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Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B C SmithM F Bassendine
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PipernoG Mancia
May 24, 2005·Digestive Diseases and Sciences·Suleyman UrazGulsen Ozbay
Feb 20, 2003·Journal of Hepatology·Stephen A Harrison, Bruce R Bacon
Jun 8, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kester CrosseCharles D Howell
May 11, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M SartoriR Boldorini
Mar 12, 2002·European Journal of Clinical Investigation·Cristina RigamontiM Sartori
Oct 18, 2003·Journal of Clinical Gastroenterology·Anne M LarsonKris V Kowdley
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Ana L C MartinelliSergio Zucoloto
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Ana L C MartinelliMarcos A Zago
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Ivonete S S SilvaMaria Lucia G Ferraz
Apr 13, 2005·Nephron. Clinical Practice·Serkan KahramanCetin Turgan
Mar 5, 2005·BMC Gastroenterology·María García-FernándezSalvador González-Barón
Apr 20, 2006·Clinical Evidence·Abdul Mohsen, Suzanne Norris
Oct 6, 2011·Archives of Pathology & Laboratory Medicine·Rachel Hudacko, Neil Theise
Nov 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Walter H Hörl, Alice Schmidt
Dec 13, 2006·Journal of Hepatology·Dominique GuyaderYves Deugnier
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Andreas GeierFrank Lammert
Dec 13, 2005·Annals of the New York Academy of Sciences·Ellen ButenskyPaul Harmatz
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhaowen ZhuWarren N Schmidt
Oct 7, 2004·Clinics in Liver Disease·Christoph EisenbachWolfgang Stremmel
Jun 14, 2005·Alimentary Pharmacology & Therapeutics·C RigamontiM Sartori
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Zeid KayaliKyle E Brown
Sep 18, 2009·Journal of Clinical Apheresis·Ivan GentileGuglielmo Borgia
Sep 5, 2009·Journal of Hepatology·Domenico GirelliGiovanna Fattovich
Sep 22, 2012·AJR. American Journal of Roentgenology·Hersh ChandaranaBachir Taouli
Oct 3, 2002·The American Journal of Gastroenterology·Vicente OrtizJoaquin Berenguer
Jan 26, 2002·The American Journal of Gastroenterology·Motoyoshi YanoKentaro Yoshioka
Sep 21, 2004·World Journal of Gastroenterology : WJG·A El-ZayadiA Saeed
Dec 9, 2016·World Journal of Radiology·Kazuhiro SaitoTaiyo L Harada

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