Oct 1, 1989

Threshold tracking provides a rapid indication of ischaemic resistance in motor axons of diabetic subjects

Electroencephalography and Clinical Neurophysiology
P WeiglP Grafe

Abstract

An early abnormality in the peripheral nerves of patients with diabetes mellitus is that it takes a long period of limb ischaemia to block conduction. As a diagnostic test, however, the procedure is time consuming (30 min of ischaemia). We have now used an electronic feedback system to track threshold changes in human motor axons during and after a short period of ischemia (10 min) induced by a pressure cuff. The strength of stimulus current applied over an appropriate nerve was adjusted to maintain a constant amplitude of muscle action potential. This method reveals an increase in excitability during the first few minutes of ischaemia, and a post-ischaemic depression. Both changes in excitability were consistently much reduced in diabetic subjects compared with normal controls.

  • References7
  • Citations25

References

  • References7
  • Citations25

Citations

Mentioned in this Paper

Surface Electromyography
Ischemia
Motor Neurons
Structure of Common Peroneal Nerve
Axon
Perineurium
Limb Ischemia
Cuff - Body Part
Diagnostic Procedure
Diabetes, Autoimmune

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