Thresholds for activation of rabbit retinal ganglion cells with a subretinal electrode

Experimental Eye Research
Ralph J Jensen, Joseph F Rizzo

Abstract

The ultimate success of a retinal prosthesis to create vision will likely depend upon developing a base of knowledge of how best to electrically stimulate the retina. Previously, we studied the responses of rabbit retinal ganglion cells (RGCs) to current pulses applied with an electrode placed on the epiretinal surface. In the present study, we examined the responses of rabbit RGCs to current pulses applied with a subretinal electrode. Single-unit extracellular recordings were made from OFF RGCs and ON RGCs in isolated retinas, which were stimulated with monophasic current pulses (0.1-50ms in duration), delivered through a 500-mum diameter electrode. All RGCs elicited one or more bursts of action potentials upon electrical stimulation of the retina. The timing of the bursts depended upon both the polarity of the electrical stimulus and the RGC type. With near-threshold current pulses, the response latencies of OFF RGCs to anodal stimulation were comparable to those of ON RGCs to cathodal stimulation, whereas the response latencies of OFF RGCs to cathodal stimulation were comparable to those of ON RGCs to anodal stimulation. Threshold currents for activation of RGCs decreased with increased pulse duration. For OFF RGCs, threshol...Continue Reading

References

Apr 28, 2000·Annals of Biomedical Engineering·C C McIntyre, W M Grill
Jul 29, 2003·Investigative Ophthalmology & Visual Science·Ralph J JensenJohn Wyatt
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Joseph F RizzoDoug Shire
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Aug 6, 2004·Japanese Journal of Ophthalmology·Satoshi SuzukiEugene de Juan
Jan 22, 2005·Journal of Neuroscience Methods·Daniel R MerrillJohn G R Jefferys
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Ralph J JensenJoseph F Rizzo
May 7, 2005·Journal of Neural Engineering·Ralph J JensenJoseph F Rizzo
Nov 19, 2005·Expert Review of Medical Devices·Jason Dowling

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Citations

May 20, 2011·Journal of Neural Engineering·Daniel K FreemanShelley I Fried
Jul 14, 2012·Journal of Neural Engineering·Lele WangD V Palanker
May 20, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Joseph F Rizzo
Apr 24, 2008·Annual Review of Biomedical Engineering·Stuart F Cogan
Aug 13, 2010·Journal of Neurophysiology·David BoinagrovDaniel Palanker
Sep 21, 2012·Journal of Neurophysiology·David BoinagrovDaniel Palanker
Aug 21, 2007·Journal of Biomaterials Science. Polymer Edition·Jessica O WinterJoseph F Rizzo
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesca MazzoniEnrica Strettoi
Apr 6, 2011·Visual Neuroscience·Eyal MargalitWallace B Thoreson
Jan 25, 2013·Journal of Neurophysiology·Seung Woo LeeShelley I Fried
May 12, 2011·Journal of Neuroscience Methods·Matthias GerhardtNiall Maccarthy
Apr 28, 2009·Computer Methods and Programs in Biomedicine·D TsaiN H Lovell
Mar 18, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Timothy L Siu, John W Morley
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Oct 1, 2011·IEEE Transactions on Biomedical Circuits and Systems·J D LoudinD V Palanker
Sep 24, 2015·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alex E HadjinicolaouMichael R Ibbotson
Feb 22, 2012·Neuroscience Letters·Jeffrey L Goldberg
Apr 29, 2015·Nature Medicine·Henri LorachDaniel Palanker
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Oct 11, 2012·Nature Photonics·Keith MathiesonDaniel Palanker
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Jun 12, 2018·Journal of Neural Engineering·Timothy B EslerHamish Meffin
Feb 28, 2007·Journal of Neural Engineering·Ralph J Jensen, Joseph F Rizzo
Sep 2, 2009·Journal of Neural Engineering·Raul G Corredor, Jeffrey L Goldberg
Jun 17, 2010·Journal of Neural Engineering·Saso JezernikManfred Morari
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Jul 30, 2019·Journal of Neural Engineering·Hee Won SeoSohee Kim
Jul 26, 2019·Journal of Neural Engineering·Elton HoDaniel Palanker

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