Thrice-daily blood pressure readings on sotalol in the treatment of hypertension: once- versus twice-daily regimen

Journal of Clinical Pharmacology
I Parvinen, E Paukkala

Abstract

Thirty patients with mild to severe essential hypertension satisfactorily controlled by twice-daily sotalol therapy entered a double-blind, crossover study comparing the efficacy, tolerability, and safety of their usual twice-daily sotalol administration with the same dosage given once daily. Each double-blind period extended eight weeks, during which blood pressure and pulse rate were recorded by a nurse three times daily on alternate days during the last week of each period in the patients' usual living conditions. Plasma sotalol concentration was measured before the morning dosage of sotalol. No statistically significant differences in the parameters were found between once- and twice-daily sotalol administration using sotalol in daily dosages from 80 to 320 mg. All patients concluded the trial, and no increase in side effects was noted during the once-daily period.

References

May 1, 1977·Clinical Pharmacology and Therapeutics·Y M Traub, J B Rosenfeld
Apr 24, 1976·British Medical Journal·A P Douglas-Jones, J M Cruickshank
Mar 11, 1977·European Journal of Clinical Pharmacology·A LehtonenT Kleimola
Apr 1, 1977·British Journal of Clinical Pharmacology·D G McDewitt, R G Shanks
Jul 3, 1976·British Medical Journal·H L Shaw
Jul 1, 1976·Acta Pharmacologica Et Toxicologica·M AnttilaH Sundquist
Jan 1, 1976·The Journal of International Medical Research·A M HarrisJ A Tweed
Apr 3, 1976·British Medical Journal·H Saarimaa
Dec 15, 1973·British Medical Journal·A J Boakes, B H Boeree
Dec 1, 1974·Postgraduate Medical Journal·P G Gooding, E Berman
Jul 1, 1970·Circulation·H BrooksL Dexter
Sep 1, 1974·Clinical Pharmacology and Therapeutics·H SundquistM Arstila
Jan 1, 1974·European Journal of Clinical Pharmacology·R GuglerH J Dengler
Aug 1, 1968·The American Journal of Cardiology·W S Frankl, L A Soloff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.