Thrichomys laurentius (Rodentia; Echimyidae) as a putative reservoir of Leishmania infantum and L. braziliensis: patterns of experimental infection.

PLoS Neglected Tropical Diseases
André Luiz R RoqueAna Maria Jansen

Abstract

The importance of the genus Thrichomys in the retention of infection and transmission of Leishmania species is supported by previous studies that describe an ancient interaction between caviomorphs and trypanosomatids and report the natural infection of Thrichomys spp. Moreover, these rodents are widely dispersed in Brazil and recognized as important hosts of other tripanosomatids. Our main purpose was to evaluate the putative role of Thrichomys laurentius in the retention of infection and amplification of the transmission cycle of Leishmania infantum and L. braziliensis. Male and female T. laurentius (n = 24) born in captivity were evaluated for the retention of infection with these Leishmania species and followed up by parasitological, serological, hematological, biochemical, histological, and molecular assays for 3, 6, 9, or 12 months post infection (mpi). T. laurentius showed its competence as maintenance host for the two inoculated Leishmania species. Four aspects should be highlighted: (i) re-isolation of parasites 12 mpi; (ii) the low parasitic burden displayed by T. laurentius tissues; (iii) the early onset and maintenance of humoral response, and (iv) the similar pattern of infection by the two Leishmania species. Both...Continue Reading

References

Jul 1, 1994·Memórias do Instituto Oswaldo Cruz·W DegraveU Lopes
Jul 1, 1993·Clinical Microbiology Reviews·G Grimaldi, R B Tesh
Oct 1, 1995·Revista de saúde pública·S Giorgio
Sep 1, 1996·Clinics in Dermatology·R W Ashford
Jun 1, 1997·Consciousness and Cognition·S P Vecera, K S Gilds
Jun 20, 2000·Parasitology Today·J StevensH Noyes
Sep 21, 2000·Memórias do Instituto Oswaldo Cruz·N R Van WynsbergheF J Andrade-Narváez
Oct 3, 2000·Advances in Parasitology·J R StevensW Gibson
May 16, 2001·Science·M E WoolhouseD T Haydon
Nov 20, 2002·Cytogenetic and Genome Research·C R BonvicinoP S D'Andrea
Dec 25, 2002·Emerging Infectious Diseases·Daniel T HaydonM Karen Laurenson
Feb 15, 2003·BMJ : British Medical Journal·Clive R DaviesShyam Sundar
Mar 11, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·R LainsonF T Silveira
May 24, 2003·Memórias do Instituto Oswaldo Cruz·Russell W RaymondSara F Kerr
Jul 2, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sinval P Brandão-FilhoJeffrey J Shaw
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J McMichael
Nov 1, 2005·Lancet·Henry W MurrayNancy G Saravia
Nov 23, 2005·Memórias do Instituto Oswaldo Cruz·Bernardo Rodrigues TeixeiraPaulo Sérgio D'Andrea
Mar 14, 2007·Clinics in Dermatology·Mark S Bailey, Diana N J Lockwood
Aug 24, 2007·The Lancet Infectious Diseases·Richard ReithingerSimon Brooker
Nov 13, 2007·Veterinary Parasitology·Maria Emília Bodini SantiagoValéria Marçal Felix Lima
Oct 3, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·H HajjaranGh H Edrissian
Oct 25, 2008·Memórias do Instituto Oswaldo Cruz·Patrícia Batista Barra Medeiros BarbosaMaria de Fátima Freire de Melo Ximenes
Dec 17, 2008·Cadernos de saúde pública·Ana Nilce Silveira Maia-ElkhouryExpedito A Luna
Jan 31, 2009·The Australasian Journal of Dermatology·Amanda Oakley, Marius Rademaker

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Citations

Apr 19, 2015·Parasites & Vectors·Rebecca Martins CardosoRodrigo Gurgel-Gonçalves
Nov 27, 2014·International Journal for Parasitology. Parasites and Wildlife·André Luiz R Roque, Ana Maria Jansen
Dec 17, 2014·PLoS Neglected Tropical Diseases·Renata Cássia-PiresAndré Luiz R Roque
Dec 8, 2016·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Fernanda Nazaré MorgadoRenato Porrozzi
Feb 21, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Elsy Nalleli Loría-Cervera, Fernando José Andrade-Narváez
Apr 13, 2013·Memórias do Instituto Oswaldo Cruz·Elsy Nalleli Loría-CerveraFernando José Andrade-Narváez
Dec 29, 2017·PloS One·Gabriel Barbosa TonelliJosé Dilermando Andrade Filho
Jun 7, 2019·The Onderstepoort Journal of Veterinary Research·Abdalla A LatifBen J Mans
May 6, 2016·Ecology· Taal LeviCarlos A Peres

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
electrophoresis
light microscopy
ELISA

Software Mentioned

BioStat
Genephor

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