Abstract
Total Health Risks in Vascular Events-calculation score (THRIVE-c) is an easy use and patient-specific outcome predictive score by computing the logistic equation with patients' continuous variables. We validated its performance in Chinese ischemic stroke patients receiving intravenous thrombolysis (IVT) therapy. We used data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) registry to validate the THRIVE-c score in patients receiving IVT therapy. We evaluated the score performance using area under the receiver operating characteristic curve (AUC). Receiver operator characteristic curve (ROC) was used to compare THRIVE-c score performance with other scores in predicting clinical outcome and symptomatic intracranial hemorrhage (SICH). Calibration was assessed by Pearson correlation coefficient and Hosmer-Lemeshow test. Among the 1,128 patients receiving IVT therapy included in this study, AUC of the THRIVE-c score for 3-month SICH, poor functional outcome, and mortality rate was 0.70 (95% CI: 0.63-0.76), 0.75 (95% CI: 0.73-0.78) and 0.81 (95% CI: 0.77-0.85), respectively. The increased THRIVE-c score was associated with higher risk of developing SICH, poor functional outcome, or mor...Continue Reading
References
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jan 30, 2007·Lancet·Nils WahlgrenUNKNOWN SITS-MOST investigators
Jan 29, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·L Derex, N Nighoghossian
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Oct 24, 2009·Lancet Neurology·Erich BluhmkiWerner Hacke
Mar 13, 2010·AJNR. American Journal of Neuroradiology·Alexander C FlintV A Rao
Mar 13, 2010·Stroke; a Journal of Cerebral Circulation·A-Ching ChaoUNKNOWN Taiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group
Feb 9, 2012·Neurology·D StrbianT Tatlisumak
Mar 24, 2012·Stroke; a Journal of Cerebral Circulation·Michael MazyaUNKNOWN SITS Investigators
Apr 24, 2012·Annals of Neurology·Daniel StrbianTurgut Tatlisumak
May 29, 2012·Lancet·Joanna M WardlawGeoff Cohen
Jul 20, 2012·Stroke; a Journal of Cerebral Circulation·Bijoy K MenonEric E Smith
Nov 6, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hooman KamelAlexander C Flint
Dec 5, 2012·CNS Neuroscience & Therapeutics·Xiao-Ling LiaoUNKNOWN Thrombolysis Implementation and Monitor of acute ischemic Stroke in China (TIMS-China) Investigators
Aug 10, 2013·Stroke; a Journal of Cerebral Circulation·Amrou SarrajSean I Savitz
Sep 28, 2013·Stroke; a Journal of Cerebral Circulation·Alexander C FlintUNKNOWN TREVO-2 Trialists
Sep 28, 2013·Stroke; a Journal of Cerebral Circulation·Alexander C FlintUNKNOWN VISTA Collaboration
Mar 8, 2014·Stroke; a Journal of Cerebral Circulation·William N WhiteleyUNKNOWN IST-3 Collaborative Group
Apr 20, 2014·Stroke; a Journal of Cerebral Circulation·Chunyan LeiZilong Hao
May 23, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Alexander C FlintUNKNOWN SWIFT and STAR trialists
Mar 3, 2015·Lancet Neurology·Xuya HuangKeith W Muir
Jun 6, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Alexander C FlintUNKNOWN SITS International and VISTA-plus investigators
Oct 27, 2015·JAMA Neurology·Shadi YaghiJoshua Z Willey
May 11, 2016·The New England Journal of Medicine·Craig S AndersonUNKNOWN ENCHANTED Investigators and Coordinators