Abstract
Kidney transplant recipients are prone to hypertension, dyslipidemia, and cardiovascular death. Hypertension is associated with hemostatic abnormalities. Thrombin activatable fibrinolysis inhibitor (TAFI) is a glycoprotein that links coagulation and fibrinolysis. The purpose of this study was to assess TAFI concentrations in renal transplant recipients in relation to blood pressure. Additionally, we evaluated thrombin activity (thrombin-antithrombin complex [TAT], prothrombin fragments 1+2 [F1+2]), thrombomodulin (TM), and the degree of plasmin generation (plasmin-antiplasmin complex [PAP]) using commercially available kits. The studies were performed on 86 renal allograft recipients (48 women, 38 men) at age range 26 to 73 years. The immunosuppressive regimen consisted of cyclosporine (CsA), prednisone, and azathioprine (n = 58) or mycophenolate mofetil (MMF; n = 28). All patients maintained sufficient and stable graft function, showing no clinical signs of rejection. In patients with hypertension (n = 68), we observed significantly higher concentrations of TAFI and of markers of thrombin generation (F1+2, TAT), and of thrombomodulin with significantly prolonged euglobulin clot lysis time (ECLT), which reflects overall fibrino...Continue Reading
References
May 1, 1990·Transplantation·L R BakerI B Kovacs
Mar 9, 1995·The New England Journal of Medicine·A Hamsten
Sep 27, 1996·Transplantation·J MalyszkoM Mysliwiec
Nov 14, 1998·Journal of Hypertension·U Ikeda, K Shimada
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T HryszkoM Mysliwiec
Dec 1, 2001·Thrombosis Research·T HryszkoM Myśliwiec
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J MalyszkoM Mysliwiec
Apr 17, 2003·Transplantation·Maria T SartoriAntonio Girolami
Oct 8, 2003·Transplantation Proceedings·J MalyszkoM Mysliwiec
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Todd F GriffithLynda A Szczech
Apr 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN Kidney Disease Outcomes Quality Initiative (K/DOQI)
Jul 30, 2004·American Journal of Hematology·Amparo SantamaríaJordi Fontcuberta
Sep 24, 2004·Current Medicinal Chemistry·Pauline F Marx
Citations
Mar 3, 2007·Clinical Biochemistry·Michael B Boffa, Marlys L Koschinsky
Jun 27, 2007·British Journal of Haematology·Mathieu GarandMarlys L Koschinsky
Aug 1, 2015·Disease Markers·Ana Paula Lucas MotaLuci Maria SantAna Dusse