Thrombin activatable fibrinolysis inhibitor in hypertensive kidney transplant recipients

Transplantation Proceedings
J S MalyszkoM Myśliwiec

Abstract

Kidney transplant recipients are prone to hypertension, dyslipidemia, and cardiovascular death. Hypertension is associated with hemostatic abnormalities. Thrombin activatable fibrinolysis inhibitor (TAFI) is a glycoprotein that links coagulation and fibrinolysis. The purpose of this study was to assess TAFI concentrations in renal transplant recipients in relation to blood pressure. Additionally, we evaluated thrombin activity (thrombin-antithrombin complex [TAT], prothrombin fragments 1+2 [F1+2]), thrombomodulin (TM), and the degree of plasmin generation (plasmin-antiplasmin complex [PAP]) using commercially available kits. The studies were performed on 86 renal allograft recipients (48 women, 38 men) at age range 26 to 73 years. The immunosuppressive regimen consisted of cyclosporine (CsA), prednisone, and azathioprine (n = 58) or mycophenolate mofetil (MMF; n = 28). All patients maintained sufficient and stable graft function, showing no clinical signs of rejection. In patients with hypertension (n = 68), we observed significantly higher concentrations of TAFI and of markers of thrombin generation (F1+2, TAT), and of thrombomodulin with significantly prolonged euglobulin clot lysis time (ECLT), which reflects overall fibrino...Continue Reading

References

Mar 9, 1995·The New England Journal of Medicine·A Hamsten
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T HryszkoM Mysliwiec
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J MalyszkoM Mysliwiec
Oct 8, 2003·Transplantation Proceedings·J MalyszkoM Mysliwiec
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Todd F GriffithLynda A Szczech
Apr 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN Kidney Disease Outcomes Quality Initiative (K/DOQI)
Sep 24, 2004·Current Medicinal Chemistry·Pauline F Marx

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