Thrombin generation in patients with thrombotic thrombocytopenic purpura.

American Journal of Hematology
H TakahashiA Shibata

Abstract

Thrombotic thrombocytopenic purpura (TTP) is thought to be caused primarily by endothelial cell injury or primary platelet agglutination. A coagulation screen usually shows normal or minimal changes, but a modest elevation of fibrinogen/fibrin degradation products (FDP) is observed in many patients with TTP. To assess the thrombin generation in vivo in TTP, plasma levels of thrombin-antithrombin III complex (TAT) were measured together with plasmin-alpha 2-antiplasmin complex (PAP) in ten patients with acute TTP. Plasma TAT [mean 6.7 +/- (SD) 3.7 micrograms/liter] as well as PAP (2.1 +/- 1.2 mg/liter) were elevated in patients with TTP as compared with healthy subjects (TAT of 1.7 +/- 0.3 microgram/liter and PAP of 0.2 +/- 0.1 mg/liter; n = 10). These findings indicate that considerable amounts of thrombin and plasmin are actually generated in TTP, although the majority of patients do not show signs of consumption coagulopathy.

References

Oct 1, 1985·The Journal of Clinical Investigation·F A Siddiqui, E C Lian
Nov 1, 1984·Annals of Internal Medicine·J G KeltonD Sheridan
Feb 1, 1984·British Journal of Haematology·S J Machin
Jan 1, 1980·Seminars in Thrombosis and Hemostasis·S S KennedyJ R Beck
Nov 1, 1981·Missouri Medicine·R FarrisJ T Peterson

❮ Previous
Next ❯

Citations

Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·B LämmleL Alberio
Feb 1, 1993·American Journal of Hematology·M HoffmanH R Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.