Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insults

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nicola MaggioMenahem Segal

Abstract

The effects of thrombin, a blood coagulation serine protease, were studied in rat hippocampal slices, in an attempt to comprehend its devastating effects when released into the brain after stroke and head trauma. Thrombin acting through its receptor, protease-activated receptor 1 (PAR1), produced a long-lasting enhancement of the reactivity of CA1 neurons to afferent stimulation, an effect that saturated the ability of the tissue to undergo tetanus-induced long-term potentiation. This effect was mediated by activation of a PAR1 receptor, because it was shared by a PAR1 agonist, and was blocked by its selective antagonist. An independent effect of thrombin involved the lowering of the threshold for generating epileptic seizures in CA3 region of the hippocampus. Thus, the experiments in a slice mimicked epileptic and cognitive dysfunction induced by thrombin in the brain, and suggest that these effects are mediated by activation of the PAR1 receptor.

Associated Clinical Trials

Citations

Jun 27, 2009·Clinical Reviews in Allergy & Immunology·Aviva KatzavJoab Chapman
Aug 1, 2013·Journal of Molecular Neuroscience : MN·Doron BushiDavid Tanne
Nov 21, 2012·Epilepsia·Karl Schoknecht, Hadar Shalev
Jul 4, 2008·Epilepsy Currents·Kevin M Kelly
Dec 20, 2013·Journal of Molecular Neuroscience : MN·Zeev ItzeksonJoab Chapman
Jul 1, 2012·Translational Stroke Research·Daniel BodmerE Sander Connolly
Oct 21, 2016·Journal of Neurotrauma·Zeev Itsekson-HayoshChaim G Pick
Sep 7, 2011·Epilepsy Research·Katarzyna LukasiukLeszek Kaczmarek
Mar 8, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Danica B Stanimirovic, Alon Friedman
Nov 2, 2012·Journal of Neurochemistry·Antoine G AlmonteJ David Sweatt
Aug 29, 2012·Annals of Neurology·Elena IsaevaGregory L Holmes
Jul 28, 2011·Developmental Neurobiology·Jakub WlodarczykAlexander Dityatev
Sep 1, 2015·Frontiers in Cellular Neuroscience·Tomasz WójtowiczJerzy W Mozrzymas
Jan 1, 2011·Epilepsy Research and Treatment·Itai WeissbergAlon Friedman
Oct 30, 2012·Neurobiology of Disease·Nicola MaggioMenahem Segal
Dec 3, 2014·Seminars in Cell & Developmental Biology·E A van VlietJ A Gorter
Dec 3, 2014·Seminars in Cell & Developmental Biology·Karl SchoknechtUwe Heinemann
Feb 15, 2015·Seminars in Cell & Developmental Biology·Yonatan SerlinAlon Friedman
Mar 5, 2013·Experimental Neurology·Nicola MaggioJoab Chapman
Oct 14, 2014·Frontiers in Cellular Neuroscience·Robert BrunkhorstWaltraud Pfeilschifter
Feb 26, 2016·Cellular and Molecular Neurobiology·Jingjing Nie, Xiaosu Yang
May 21, 2015·Arquivos de neuro-psiquiatria·João Paulo Lopes BornDaniel Leite Góes Gitaí
Oct 13, 2017·International Journal of Molecular Sciences·Ciro De LucaMichele Papa
May 16, 2018·Journal of Neuroscience Research·Doron BushiDavid Tanne
Oct 16, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A M FeyissaJ F Meschia
Sep 13, 2013·The Journal of Biological Chemistry·Ravisekhar GadepalliGadiparthi N Rao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.