Thrombin inhibition in the acute phase of ischaemic stroke using argatroban

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
K KarioT Matsuo

Abstract

We studied the effect of argatroban, a new selective thrombin inhibitor, on the haemostatic system in seven patients with acute ischaemic stroke (the argatroban group). Argatroban was infused continuously at 2.5 mg/h for the first 48 h, and then 10 mg of argatroban was infused over 3 h twice a day on days 3-7. The placebo group consisted of six acute ischaemic stroke patients. As a combination therapy, intravenous administration of glycerol was also performed at the same time in five of the seven patients in the argatroban group and in four of the six patients in the placebo group. D-dimer levels were measured by a latex photometric immunoassay that allowed immediate quantitative assessment. The D-dimer levels of our 13 patients with acute ischaemic stroke were raised at the time of admission (day 1) and 69% of the values were above the 97th percentile ( > 500 ng/ml) in healthy subjects. D-dimer levels were significantly reduced in the argatroban group on days 2 and 7 after admission when compared with the placebo group (day 2: P = 0.032; day 7: P = 0.046). Thus, haemostatic activation occurred in acute ischaemic stroke was effectively blocked by argatroban.

Citations

Apr 10, 2007·Journal of Neurology·Naohisa HosomiUNKNOWN Japan Standard Stroke Registry Study Group
Jul 19, 2002·Seminars in Hematology·Karen L Kaplan, Charles W Francis
Jan 1, 1999·Neuropathology : Official Journal of the Japanese Society of Neuropathology·I AkiguchiH Budka
Jul 5, 2005·Expert Opinion on Investigational Drugs·W JeskeJ Fareed
May 13, 2003·Expert Opinion on Pharmacotherapy·Karen L Kaplan
Jan 29, 2009·AACN Advanced Critical Care·Melanie L Sparks
Jun 3, 2004·Best Practice & Research. Clinical Haematology·Jawed Fareed, Walter P Jeske
Apr 17, 2001·The Annals of Pharmacotherapy·L M KondoB S Wiggins
Sep 14, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y YonedaM Tabuchi
Feb 15, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Craig P McFarland, Stuart E Lind
Jul 28, 2018·Neurological Research·Lei ChenJunxiu Yang
Mar 13, 2015·The Cochrane Database of Systematic Reviews·Peter A G SandercockEdward J Kane
Apr 24, 2004·The Cochrane Database of Systematic Reviews·E RighettiS Ricci
Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Shinsuke MiyaharaYoshihito Honda
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Yukihiro YonedaEtsuro Mori
Dec 17, 2015·Stroke; a Journal of Cerebral Circulation·Tomoki WadaNaoki Yahagi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.