Thrombin-Responsive Gated Silica Mesoporous Nanoparticles As Coagulation Regulators

Langmuir : the ACS Journal of Surfaces and Colloids
Ravishankar BhatRamón Martínez-Máñez

Abstract

The possibility of achieving sophisticated actions in complex biological environments using gated nanoparticles is an exciting prospect with much potential. We herein describe new gated mesoporous silica nanoparticles (MSN) loaded with an anticoagulant drug and capped with a peptide containing a thrombin-specific cleavage site. When the coagulation cascade was triggered, active thrombin degraded the capping peptidic sequence and induced the release of anticoagulant drugs to delay the clotting process. The thrombin-dependent response was assessed and a significant increase in coagulation time in plasma from 2.6 min to 5 min was found. This work broadens the application of gated silica nanoparticles and demonstrates their ability to act as controllers in a complex scenario such as hemostasis.

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Citations

Nov 26, 2016·Advanced Materials·Yuqi ZhangZhen Gu
Nov 20, 2016·Chemistry : a European Journal·Mar OrovalRamón Martínez-Máñez
Aug 30, 2017·Chemical Society Reviews·Jia WenShiguo Sun
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Mar 1, 2017·ChemPlusChem·Luís PlaFélix Sancenón
May 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Antoni Llopis-LorenteFélix Sancenón
Sep 5, 2020·Pharmaceutics·Shi Su, Peter M Kang
Aug 26, 2017·Advanced Healthcare Materials·Bastiaan D Ippel, Patricia Y W Dankers
Dec 2, 2017·International Journal of Pharmaceutics·Jicheng YuZhen Gu
Jun 8, 2021·Chemical Science·Miriam de J Velásquez-HernándezPaolo Falcaro

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