PMID: 9533629Apr 9, 1998Paper

Thrombin-sensitive peptide linkers for biological signal-responsive drug release systems

Peptides
M TaniharaY Kakimaru

Abstract

We have previously reported an elevation of thrombin-like activity in infected wound exudates. Therefore, using this enzymatic activity as a biological signal, a system which can release an antimicrobial drug at infected wounds was investigated. In this paper, we report thrombin-sensitive peptide linkers, the key component of this system. Starting from amino acid sequences of the cleavage site in fibrinogen, which is the substrate of thrombin, we synthesized some thrombin-sensitive peptide linkers. We constructed devices in which the thrombin-sensitive peptide linker interconnected between polyvinyl alcohol hydrogel and gentamicin. The device was able to release gentamicin in response to thrombin.

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Citations

Sep 18, 1998·Journal of Biomedical Materials Research·Y SuzukiY Shimizu
Jul 27, 1999·Journal of Biomedical Materials Research·Y SuzukiY Shimizu
Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N A PeppasH Ichikawa
Dec 2, 2008·Biological & Pharmaceutical Bulletin·Jong Oh KimHan-Gon Choi
Jan 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shahriar AbsarFakhrul Ahsan
Mar 7, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christian WischkeAndreas Lendlein
Jul 6, 2014·AAPS PharmSciTech·Naeema MayetViness Pillay
May 7, 1999·Journal of Pharmaceutical Sciences·M TaniharaY Fukunishi
Oct 9, 2008·Advanced Drug Delivery Reviews·Mehrdad HamidiPedram Rafiei
Apr 29, 2008·International Journal of Pharmaceutics·Jong Oh KimHan-Gon Choi
Sep 22, 2007·Advanced Drug Delivery Reviews·Michael H Smolensky, Nicholas A Peppas
Dec 13, 2005·Biomaterials·Peng Wu, David W Grainger
Jul 10, 2012·International Journal of Pharmaceutics·Sorada KanokpanontPornanong Aramwit
Sep 2, 2011·Bioorganic & Medicinal Chemistry·Geoffray LericheAlain Wagner
Jun 19, 2014·Journal of Biomaterials Science. Polymer Edition·Chisa OzakiYasuhiko Tabata
Dec 17, 2016·Therapeutic Delivery·Jessica E PullanAmanda E Brooks
Aug 28, 2021·Advanced Healthcare Materials·Li ZhaoRyan F Donnelly

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