Thrombocyte transfusion: clinical aspects, follow-up and complications

Klinische Wochenschrift
D Söhngen, W Schneider

Abstract

Thrombocytopenia is the most common cause of bleeding tendency, and, if due to impaired platelet production, is best treated by platelet transfusions. Prophylactic transfusions for asymptomatic patients should be considered if platelet count is below 20,000/microliters. However, if bleeding occurs or surgery is inevitable, platelet count should be maintained above 50,000/microliters. The benefit of platelet transfusions has to be balanced against risks like fever, infections and haemolysis. The effectiveness of platelet transfusions should be examined after 1 and 24 hrs by measuring the corrected count increment (CCI). Not only alloimmunization is a reason for unsatisfactory platelet increments. A poor CCI can also be due to fever, sepsis, hepato-splenomegaly or special drugs, which must be taken into account when assessing the demand for platelet transfusions.

References

Feb 4, 1978·Lancet·J SolomonE Beutel
Sep 1, 1976·American Journal of Clinical Pathology·A T AndrewsJ K Reihart
Jul 1, 1986·Transfusion·Joanna Mary HealT Mayer
Sep 1, 1986·Transfusion·G MoroffN L Luban
Nov 1, 1986·British Journal of Haematology·C Mueller-Eckhardt
Jul 27, 1972·The New England Journal of Medicine·L A Harker, S J Slichter
May 20, 1971·The New England Journal of Medicine·J S ThompsonA Simmons
Jan 1, 1980·Annual Review of Medicine·S J Slichter
Mar 1, 1982·Scandinavian Journal of Haematology·B C McLeodT Vaithianathan
May 3, 1962·The New England Journal of Medicine·L A GAYDOSN MANTEL

Citations

Oct 13, 2004·The Oncologist·Jose Pereira, Tien Phan
Jan 21, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C F WeberM M Müller

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