PMID: 9174546Apr 1, 1997Paper

Thrombocytopenia and complement activation under recombinant TNF alpha/IFN gamma therapy in man

Annals of Hematology
I MichelmannU Göbel

Abstract

Infusions of recombinant human tumor necrosis-alpha plus recombinant human interferon-gamma (rhTNF alpha/rhIFN gamma) were assessed in two patients with Ewing's sarcoma. We analyzed platelet count, coagulation and the terminal complement complex (TCC). During cycles with continuous rhTNF alpha-infusions we found a rapid, marked decrease of platelet count (minus 90% of initial values) and a simultaneous increase of TCC (plus 84% of initial values) at day 4. At days 5-7 a spontaneous increase of platelet count and decrease of TCC were visible. Short-term infusion led to a milder, continuous decrease of platelet counts and to a moderate, progressive increase of TCC at days 5-7. Bleeding occurred only as petechia and mild hemoglobinuria. There was no effect related to the dosage of rhTNF alpha or rhIFN gamma. Relevant differences were seen only in the variable time courses of rhTNF alpha application. Ex vivo analysis of one patient's platelets showed no cytokine-related effect on induced aggregation according to Born. Additionally, we analyzed in vitro effects of the cytokines on platelet count, platelet aggregation, and the assembly of TCC in platelet membranes. No effects were found after incubation of platelet-rich plasma (PRP) ...Continue Reading

Citations

Oct 31, 1998·Current Opinion in Immunology·F J LejeuneD Liénard
Feb 5, 2002·Microbes and Infection·Herbert SchmitzAchim Hoerauf
Jun 17, 2005·Annals of the Rheumatic Diseases·A FamilianC E Hack
May 21, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Folker Wenzel, Günther Giers
May 11, 2013·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Titus S IbekwePeter O Okokhere
Sep 19, 2016·La Revue de médecine interne·M BobotJ-M Durand
Mar 9, 2013·Toxicologic Pathology·Nancy E Everds, Jacqueline M Tarrant
Mar 13, 2018·Internal Medicine·Yushiro EndoAtsushi Kawakami
Mar 5, 2009·American Journal of Hematology·Ron RamPia Raanani
Nov 21, 2020·Expert Opinion on Biological Therapy·Ana Lorenzo-Vizcaya, David A Isenberg

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