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Thrombocytopenia in c-mpl-deficient mice

Science

Sep 2, 1994

A L GurneyM W Moore

Abstract

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-...read more

Mentioned in this Paper

Shuttle Vectors
Thrombocytopenia
Megakaryocytes
Thrombopoiesis
MPL wt Allele
Thrombopoietin Receptor
Recombination, Genetic
Hematopoiesis, Medullary
Investigation of Megakaryocytes
Receptors, Immunologic
65
Paper Details
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Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

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F J de SauvageM W Moore
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Thrombocytopenia in c-mpl-deficient mice

Science

Sep 2, 1994

A L GurneyM W Moore

PMID: 8073287

DOI: 10.1126/science.8073287

Abstract

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-...read more

Mentioned in this Paper

Shuttle Vectors
Thrombocytopenia
Megakaryocytes
Thrombopoiesis
MPL wt Allele
Thrombopoietin Receptor
Recombination, Genetic
Hematopoiesis, Medullary
Investigation of Megakaryocytes
Receptors, Immunologic
65

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Science eTOC

Science Magazine is a peer-reviewed academic journal of the American Association for the Advancement of Science. Find the latest research from Science here.

Related Papers

The Journal of Experimental Medicine

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

The Journal of Experimental MedicineFebruary 1, 1996
F J de SauvageM W Moore
Paper Details
References
  • References
  • Citations313
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations313
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