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Thrombocytopenia in c-mpl-deficient mice

Science

Sep 2, 1994

Austin L GurneyMarilyn Moore

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Abstract

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-...read more

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  • Thrombocytopenia in c-mpl-deficient mice

    Science

    Sep 2, 1994

    Austin L GurneyMarilyn Moore

    PMID: 8073287

    DOI: 10.1126/science.8073287

    Abstract

    Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-...read more

    61

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