Thrombocytosis as a prognostic factor in polymyalgia rheumatica: characteristics determined from cluster analysis

Therapeutic Advances in Musculoskeletal Disease
Keigo HayashiJun Wada

Abstract

This study aimed to identify the clinical subgroups of polymyalgia rheumatica (PMR) using cluster analysis and compare the outcomes among the identified subgroups. We enrolled patients with PMR who were diagnosed at Okayama University Hospital, Japan between 2006 and 2017, met the 2012 European League Against Rheumatism/American College of Rheumatology provisional classification criteria for PMR, and were treated with glucocorticoids. Hierarchical cluster analysis using variables selected by principal component analysis was performed to identify the clusters. Subsequently, the outcomes among the identified clusters were compared in the study. The primary outcome was treatment response at 1 month after commencement of treatment. The secondary outcome was refractory clinical course, which was defined as the requirement of additional treatments or relapse during a 2-year observational period. A total of 61 consecutive patients with PMR were enrolled in the study. Their mean age was 71 years, and 67% were female. Hierarchical cluster analysis revealed three distinct subgroups: cluster 1 (n = 14) was characterized by patients with thrombocytosis (all patients showed a platelet count of >45 × 10⁴/µl), cluster 2 (n = 38), by patients ...Continue Reading

References

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Citations

Aug 8, 2020·Nature Reviews. Rheumatology·Dario CamellinoChristian Dejaco
Oct 13, 2020·International Journal of Rheumatic Diseases·Claire E OwenRussell R C Buchanan

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Methods Mentioned

BETA
ESR
PCA

Software Mentioned

JMP

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