Thromboelastography Is Associated With Surrogates for Bleeding After Pediatric Cardiac Operations

The Annals of Thoracic Surgery
Sirisha EmaniSitaram M Emani

Abstract

Perioperative bleeding is a common complication in pediatric patients undergoing cardiac operation. Although thromboelastography (TEG) has been used in patients undergoing adult cardiac operation, limited data are available in pediatric patients. We hypothesize that TEG variables may be associated with surrogate end points for postoperative bleeding in pediatric patients undergoing complex cardiac operation. In a retrospective study, TEG was obtained after protamine administration and on admission to the intensive care unit (ICU) in pediatric patients (≤18 years) undergoing cardiac operation that required cardiopulmonary bypass. A composite end point of extended blood product transfusion or surgical re-exploration for bleeding was used as a surrogate for perioperative bleeding. TEG variables were compared between patients who did or did not reach the composite end point. The study included 511 pediatric patients undergoing complex cardiac operation. The composite end point was reached in 52% of patients with maximum amplitude (MA) less than 45 mm compared with 31% with MA of 45 mm or more (p < 0.001). With the use of multivariable regression analysis, MA less than 45 mm was independently associated with the composite end point ...Continue Reading

Citations

Mar 14, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sirisha EmaniSitaram M Emani
Oct 23, 2020·Transfusion·Thorsten Haas, David Faraoni
Jan 26, 2021·Frontiers in Pediatrics·Alison B Nair, Robert I Parker
Jan 30, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lynn A SleeperSirisha Emani
Mar 4, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Prashant Dev Aravind, Gail M Annich
Mar 6, 2021·The Annals of Thoracic Surgery·Sirisha EmaniSitaram M Emani
Sep 18, 2021·Pediatric Blood & Cancer·Ashish A AnkolaChristina J VanderPluym
Jan 7, 2022·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jill M CholetteUNKNOWN Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaborati

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