PMID: 9636913Jun 24, 1998Paper

Thromboelastography with heparinase in orthotopic liver transplantation

Journal of Cardiothoracic and Vascular Anesthesia
E G PivalizzaF S King

Abstract

To investigate the role of heparin in the postreperfusion coagulopathy during liver transplantation with heparinase-guided thromboelastography. A prospective, interventional study. A university-affiliated hospital. Twenty-six patients undergoing orthotopic liver transplantation (OLT). Blood drawn at five intervals for thromboelastography assessment with native (12 patients) or celite blood (14 patients) compared with simultaneous thromboelastography traces with added heparinase. In the native samples, the prolonged R (reaction) and K (coagulation) time and decreased alpha angle were corrected in heparinase thromboelastograph traces immediately before reperfusion and 10 minutes postreperfusion. In the celite-accelerated samples, the heparinase traces showed correction of the R and K times and alpha angle only at the 10-minute postreperfusion stage. In seven patients who had thromboelastography performed after protamine administration, there were no differences between celite and heparinase-celite traces. Heparinase-treated thromboelastography offered compelling evidence for the presence of heparin-like activity after liver graft reperfusion. The objective evidence provided by this modification of thromboelastography-guided prota...Continue Reading

References

Aug 1, 1987·Transplantation Proceedings·K G BellaniJ J Buckley

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Citations

Apr 6, 2004·Critical Care Medicine·Richard A Wiklund
Apr 20, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alphan KupesizMeera Chitlur
Jul 30, 2004·Anesthesia and Analgesia·Vance G NielsenThomas M Burch
Jan 29, 2016·British Journal of Haematology·Gregory A Hans, Martin W Besser
Sep 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Marco RanucciAndrea Ballotta
Jan 20, 2009·Clinics in Liver Disease·M SenzoloA K Burroughs
Feb 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Marco SenzoloAndrew K Burroughs
Dec 17, 2008·Pediatric Transplantation·Glauber GouvêaJosé Manoel Martinho
Oct 18, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Ramona Nicolau-RaducuBobby Nossaman
Jul 30, 2004·Anesthesia and Analgesia·Vance G NielsenDale A Parks
Aug 11, 2017·Anesthesia and Analgesia·Katherine T ForkinJulie L Huffmyer
Feb 26, 2004·Anesthesia and Analgesia·Vance G Nielsen, John P Crow
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Seema AgarwalSusan V Mallett
Sep 24, 2009·European Journal of Gastroenterology & Hepatology·Derya KarakocAhmet Ozenc
Aug 29, 2001·Anesthesia and Analgesia·E G PivalizzaR P Wood
Nov 10, 2020·Clinical Liver Disease·Abhishek Shenoy, Nicolas M Intagliata
Sep 26, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Todd A OstomelGalen D Stucky

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