PMID: 3855365Feb 15, 1985Paper

Thromboembolic complications associated with L-asparaginase therapy. Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma

Cancer
O KucukR M Vazquez

Abstract

A case of an 18-year-old woman with acute lymphoblastic leukemia who developed L-asparaginase-associated stroke and subclavian vein thrombosis is presented. The latter was also associated with a Hickman central venous catheter. Thrombotic complications occurred when plasma levels of plasminogen and antithrombin III were still markedly reduced as a result of L-asparaginase therapy, although the fibrinogen had recovered from its lower levels. The stroke was treated with fresh frozen plasma and the subclavian vein thrombosis was treated with streptokinase and fresh frozen plasma. L-asparaginase and Hickman-associated coagulopathy is reviewed and the treatment is discussed.

References

Jan 1, 1978·Medical and Pediatric Oncology·R H SillsJ A Stockman
Nov 23, 1979·JAMA : the Journal of the American Medical Association·F R ArkoW A MacLeod
Mar 1, 1976·Cancer Treatment Reviews·A M Mauer, J V Simone
Aug 1, 1972·Cancer·V J LandT E Williams
Feb 1, 1970·Cancer·H F OettgenJ H Burchenal
Jun 1, 1971·Annals of Internal Medicine·R L CapizziR E Handschumacher
Nov 1, 1969·American Journal of Epidemiology·P E SartwellH E Smith
May 17, 1980·Lancet·J ConardM Samama
Mar 1, 1983·The Journal of Pediatrics·W Muntean
Apr 1, 1983·The Journal of Pediatrics·G PastoreM Lange
Jun 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C H PuiJ V Simone
Dec 1, 1980·American Journal of Surgery·J H ThomasA S Hermreck
May 15, 1982·The Medical Journal of Australia·P Crea
Jan 1, 1980·Medical and Pediatric Oncology·G R Buchanan, C A Holtkamp
Dec 1, 1950·The American Journal of Medicine·S W COSGRIFFW VOGT
Nov 3, 1951·Journal of the American Medical Association·S W COSGRIFF

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Citations

Jan 1, 1994·Journal of Neuro-oncology·L Thoron, E Arbit
Jan 1, 1996·Breast Cancer Research and Treatment·C RellaF Schittulli
Mar 1, 2010·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sanju CyriacKarpurmath V Shashidhar
Mar 1, 1992·Pediatric Neurology·T F BarronR R Clancy
Apr 11, 2003·Clinics in Chest Medicine·John A Heit
Nov 21, 2007·Hematology·Hau C Kwaan
Jul 22, 2008·Magyar onkologia·György Blaskó
Nov 3, 2010·Journal of Pediatric Neurosciences·Nisar A WaniUmar A Qureshi
Jan 1, 1992·The British Journal of Radiology·N K ForemanJ W Langston
Nov 26, 2010·Expert Review of Hematology·Hau C Kwaan, Timothy Huyck
Jan 1, 1997·Cancer Investigation·S J Kempin
Jan 1, 1992·Medical and Pediatric Oncology·N K ForemanW M Crist
Jan 1, 1992·Medical and Pediatric Oncology·J M Eguiguren, C H Pui
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·John A HeitRichard H White
Jun 9, 2009·The Journal of Emergency Medicine·Antonio E Muñiz
Mar 17, 2009·Best Practice & Research. Clinical Haematology·Ulrike Nowak-GöttlLesley G Mitchell
Oct 24, 2014·Thrombosis and Haemostasis·V De StefanoE Rossi
Jul 15, 2004·Techniques in Vascular and Interventional Radiology·Christopher M BulgerNilesh H Patel
Dec 1, 1988·Blood Reviews·C H Beresford
Jun 1, 1987·Journal of Clinical Pharmacy and Therapeutics·S M DonohueI M Franklin
Jun 1, 1996·The Journal of Pediatrics·D N KoronesJ P Harris
Mar 12, 2003·Hematology/oncology Clinics of North America·Hau C Kwaan, Chadi Nabhan
Jun 17, 2015·Nature Reviews. Cardiology·John A Heit
Sep 24, 2013·Pediatric Neurology·Melissa Chung, Warren D Lo
May 8, 2000·Medical and Pediatric Oncology·K Z OmarH P Lin
Dec 7, 2000·Journal of Child Neurology·N L Antunes
Sep 25, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maurizio ZangariGuido Tricot
Sep 26, 2019·The Journal of Vascular Access·Minh-Ha TranPhu N Tran
Jan 15, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stefano MazzoleniModesto Carli
Jan 1, 1996·European Journal of Haematology·U Nowak-GöttlH Jürgens

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