Thromboembolic complications in renal allograft recipients. A report from the prospective randomized study of cyclosporine versus azathioprine-antilymphocyte globulin

Transplantation
S A GruberD S Fryd

Abstract

The incidence of arterial and venous thromboembolic complications was compared in 224 renal allograft recipients who were prospectively randomized and stratified by risk to treatment with either cyclosporine-prednisone (CsA-P) (n = 117) or azathioprine-prednisone-antilymphocyte globulin (AZA-P-ALG) (n = 107). Thirteen CsA patients (11%) had 22 thromboembolic events, while 19 AZA patients (18%) had 24 events (P = 0.22). There was no significant difference between the 2 regimens in the number of patients with each type of venous or arterial event or in the number of patients with multiple or lethal events. The incidence of "minor" complications (all except myocardial infarction and stroke) in the related donor subgroup (n = 85) and the overall incidence of thromboembolism in the diabetic subgroup (n = 125) were both significantly higher in AZA-treated patients (P = 0.008 and 0.045, respectively). Thus, CsA immunosuppression does not appear to be a risk factor for thromboembolic disease, and it may in fact lower the incidence of thromboembolism in diabetic renal allograft recipients.

Citations

Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·H HamiltonD Kahn
Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Feb 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M YeatmanJ Wallwork
Mar 15, 2000·Transplantation Proceedings·J P RerolleD Glotz
Nov 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshitaka TayamaKenji Kihira
Sep 18, 2010·Inflammatory Bowel Diseases·Naamah L ZitomerskyCameron C Trenor
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John Fung, Amadeo Marcos
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G H Neild
Jan 6, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Harry J Ward
Jan 11, 2017·The Cochrane Database of Systematic Reviews·Penny HillAngela C Webster

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