Sep 1, 1977

Thromboembolism in Hageman trait

American Journal of Clinical Pathology
R A McPherson

Abstract

The case of a patient with severe deficiency of Hageman factor (factor XII) in whom a thrombus embolized to arteries in a lower extremity is described. In addition to its action in intiating blood clotting through the intrinsic pathway, Hageman factor can influence kinin generation, fibrinolysis, and activation of complement. While individuals with Hageman factor deficiency have no hemorrhagic disorder, this case emphasizes the role factor XII may normally assume in clot dissolution.

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Mentioned in this Paper

Biochemical Pathway
Arterial System
Factor XII Deficiency
F12
Blood Coagulation Disorders
Kinins
Thromboembolism
Assay of Fibrinolysis
Blood Clot
Fibrinolysis

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