PMID: 8956663Dec 1, 1996Paper

Thrombogenesis in mitral regurgitation and aortic stenosis

Angiology
G Y LipG D Lowe

Abstract

The exact mechanisms for thrombus formation in patients with valvular heart disease have not been clearly defined. Abnormalities in plasma coagulation factors indicative of a prothrombotic state may in part account for the risk of stroke and thromboembolism in such patients. The aim of this study was, therefore, to determine the effects of mitral regurgitation (MR) and aortic stenosis (AS) on plasma fibrinogen or fibrin D-dimer levels as indices of a thrombogenic (or prothrombotic) state. A total of 25 patients with valve disease in sinus rhythm were studied: 12 patients (all women; mean age fifty-five years, sem 3.3) with MR; and 13 patients (7 men, 6 women; mean age fifty-seven years, sem 3.5) with AS were studied. Patients with MR had a median plasma fibrinogen that was significantly elevated when compared with female population values (median difference 0.62 g/L; 95% confidence intervals (CI) 0.27 to 1.05, P = 0.0016). However, these patients had a median plasma fibrin D-dimer that was lower than that for population controls (median difference 21 ng/mL; 95% CI 0 to 38, P = 0.05). Patients with aortic valve disease had a median plasma fibrinogen that was significantly increased when compared with population controls (median ...Continue Reading

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Citations

Jul 29, 2000·The American Journal of Cardiology·I R GoldsmithG Y Lip
Jan 6, 2005·American Journal of Veterinary Research·Inge TarnowHenrik D Pedersen
Sep 16, 2008·Research in Veterinary Science·S G MoesgaardL H Olsen
Jan 4, 2001·The American Journal of Cardiology·I R GoldsmithG Y Lip
Dec 21, 2010·International Journal of Cardiology·Claudia LoardiAlessandro Parolari
Sep 3, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael GliksonBernhard Meier
Sep 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonUNKNOWN ESC Scientific Document Group

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