Abstract
The exact mechanisms for thrombus formation in patients with valvular heart disease have not been clearly defined. Abnormalities in plasma coagulation factors indicative of a prothrombotic state may in part account for the risk of stroke and thromboembolism in such patients. The aim of this study was, therefore, to determine the effects of mitral regurgitation (MR) and aortic stenosis (AS) on plasma fibrinogen or fibrin D-dimer levels as indices of a thrombogenic (or prothrombotic) state. A total of 25 patients with valve disease in sinus rhythm were studied: 12 patients (all women; mean age fifty-five years, sem 3.3) with MR; and 13 patients (7 men, 6 women; mean age fifty-seven years, sem 3.5) with AS were studied. Patients with MR had a median plasma fibrinogen that was significantly elevated when compared with female population values (median difference 0.62 g/L; 95% confidence intervals (CI) 0.27 to 1.05, P = 0.0016). However, these patients had a median plasma fibrin D-dimer that was lower than that for population controls (median difference 21 ng/mL; 95% CI 0 to 38, P = 0.05). Patients with aortic valve disease had a median plasma fibrinogen that was significantly increased when compared with population controls (median ...Continue Reading
References
Dec 1, 1978·Circulation·D J SahnA Weyman
Mar 7, 1992·Lancet·R G Hart
Aug 1, 1992·The American Journal of Cardiology·L M TsaiC M Kwan
Aug 1, 1991·Journal of the American College of Cardiology·I W BlackW F Walsh
Aug 1, 1991·Circulation·J A Cairns, S J Connolly
Dec 8, 1990·Lancet·T HofmannH Just
Mar 1, 1990·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Y T ChenB N Chiang
Feb 1, 1989·Chest·D G ShermanR G Hart
Mar 15, 1989·Journal of the American College of Cardiology·S S MazeW R Parry
May 1, 1986·Annals of Internal Medicine·R S MeltzerV Fuster
Jan 1, 1987·Circulation·F HelmckeR P Gatewood
Oct 1, 1985·Journal of the American College of Cardiology·S BeppuS Izumi
May 17, 1980·Lancet·T W MeadeM Brozovié
Jul 1, 1983·Stroke; a Journal of Cerebral Circulation·M NishideK Tsuji
Aug 23, 1984·The New England Journal of Medicine·L WilhelmsenG Tibblin
Sep 1, 1995·Clinical Science·G Y Lip, G D Lowe
Jun 1, 1995·British Heart Journal·G Y LipF G Dunn
Sep 1, 1995·The American Journal of Cardiology·G Y LipF G Dunn
Jun 15, 1993·Annals of Internal Medicine·E Ernst, K L Resch
Citations
Jul 29, 2000·The American Journal of Cardiology·I R GoldsmithG Y Lip
Apr 18, 2000·Heart·I R GoldsmithG Y Lip
Apr 18, 2000·Heart·T SuzukiT Yamazaki
Jan 6, 2005·American Journal of Veterinary Research·Inge TarnowHenrik D Pedersen
Jan 13, 2009·Lancet·Timothy WatsonGregory Y H Lip
Sep 16, 2008·Research in Veterinary Science·S G MoesgaardL H Olsen
Jan 4, 2001·The American Journal of Cardiology·I R GoldsmithG Y Lip
Dec 21, 2010·International Journal of Cardiology·Claudia LoardiAlessandro Parolari
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·G W PettyD O Wiebers
Sep 3, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael GliksonBernhard Meier
Sep 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonUNKNOWN ESC Scientific Document Group
Sep 20, 2019·Cardiology Research and Practice·Do Van ChienPham Nguyen Son
May 5, 1999·Neurology·D TanneS R Levine