Thrombogenic Risk in Patients With Atrial Fibrillation: Importance of Comorbid Conditions and Intracardiac Changes

JACC. Clinical Electrophysiology
Han S LimPrashanthan Sanders

Abstract

This study sought to determine the differences between the prothrombotic properties and chamber characteristics in patients with lone atrial fibrillation (AF) and those with AF and comorbidities. Thromboembolic risk is increased in patients with AF; however, whether this is due to AF per se or its comorbidities remains unclear. A total of 87 patients undergoing ablation were prospectively recruited for the study, including 30 patients with lone AF, 30 patients with AF and comorbidities in sinus rhythm, and 27 patients with left-sided accessory pathways as controls. Blood samples were obtained from the left atrium (LA), right atrium (RA), and femoral vein (FV) after transseptal puncture. Platelet activation (P-selectin) was measured by flow cytometry. Thrombin generation (thrombin-antithrombin [TAT] complex), endothelial dysfunction (asymmetric-dimethylarginine [ADMA]), and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked immunosorbent assay. Platelet activation in the LA was significantly elevated compared to that in the FV in patients with lone AF and those with AF and comorbidities compared with that in the FV (p < 0.05 respectively). Thrombin generation was significantly elevated...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Jun 27, 2000·Journal of Cardiovascular Electrophysiology·P JaïsJ Clémenty
Jan 12, 2001·The American Journal of Cardiology·D FengG H Tofler
May 3, 2008·Journal of the American College of Cardiology·Joseph G AkarDavid J Wilber
Apr 4, 2009·Journal of the American College of Cardiology·Martin K StilesPrashanthan Sanders
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Scott R WilloughbyPrashanthan Sanders
Oct 12, 2010·International Journal of Cardiology·Andreas GoetteStefanie M Bode-Böger
Jan 22, 2013·Journal of the American College of Cardiology·Han S LimPrashanthan Sanders
Jul 30, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Han S LimPrashanthan Sanders
Dec 3, 2014·Journal of the American College of Cardiology·Rajeev K PathakPrashanthan Sanders

❮ Previous
Next ❯

Citations

Mar 11, 2020·International Journal of Molecular Sciences·Gerrit M GrosseChi-Un Choe
Mar 30, 2021·Mayo Clinic Proceedings·Michel T CorbanAmir Lerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Silvia Montoro-GarcíaG Y Lip
© 2022 Meta ULC. All rights reserved